Abstract
The results of treatment of 104 patients with large (30–40 mm) and giant (40 mm) vestibular schwannomas were analyzed. The primary tumors were seen in 89 patients, residual and reccurrence tumors – 15 cases. Stereotactic radiosurgery was used in 15 patients with subtotal and partial removal of tumor, and radiotherapy was done in one patient with repeated partial removal. Mortality rate was 2.88% (2 patients after primary surgery and one patient after reoperation). The main reasons of the death were disgemic disorders in the brainstem. Dysfunction of cranial nerves was increased after surgery. Following radiosurgery the tumor grouth control was achieved in 92% of patients. Surgery was done in 104 patients with large and giant vestibular schwannomas (100%), combined treatment – in 15 patients (14.4%). The total resection of tumors was possible in 18 patients (17.3%), subtotal – in 42 patients (40.4%), partial removal – in 44 patients (42.3%). Combined treatment may be employed as treatment strategies for incomplete removal of large, and giant vestibulas schwannomas for the preservation of facial nerve.References
Lancer M. Epidemiology, pathogenesis and genetics of acoustic tumors / M. Lancer, S.A. Sussman, K. Frazer // Otolaryngol. Clin. North. Am. – 1992. – Vol. 25. – P. 499–520.
Pollock B.E. Vestibular schwannoma management in the next century: A. radiosurgical perspective / B.E. Pollock, L.D. Lunsford, G. Noren // Neurosurgery. –1998. – Vol. 43. – P. 475–483.
Whitmore R.C. Decision analysis of treatment options for vestibular schwannoma / R.C. Whitmore, C. Urban // J. Neurosurgery. – 2011. – Vol. 114. – P. 400–413.
Злотник Э.И. К вопросу о тотальном удалении неврином слухового нерва / Э.И. Злотник, И.А. Склют, Р.А. Куприяненко // Вопросы нейрохирургии. – 1961. – № 1. – C. 41–44.
El-Kashlan H.K. Recurence of acoustic neuroma after incomplete resection / H.K. El-Kashlan, Y. Zeintoun, H.A. Arts // Am. J. Otol. – 2000. – Vol. 21. – P. 389–392.
Gamache F. Acoustic Neuroma / eds. M. Tos, J. Thomsen. – Amsterdam: Kugler, 1992. – P. 705–707.
Хирургическое лечение неврином VIII нерва больших и гигантских размеров: особенности хирургической тактики и результаты лечения / М.М. Тастанбеков, В.Е. Олюшин, В.П. Берснев и др. // Нейрохирургия. – 2010. – № 3. – С. 25–29.
Improving outcomes in patient with vestibular schwannomas: microsurgery versus radiosurgery / J.M. Sarmiento, S. Patel, D. Mukherjee, C.G. Patil // J. Neurosurgical Sciences. – 2013. – Vol. 57. – P. 23–44.
Radiosurgery as treatment for acoustic neuroma. Ten years’experience / J.L. Carratala, V.E. Garcia, M.O. Albroch et al // Acta Otorhinolaryngol Esp. – 2014. – Vol. 65. – P. 327–331.
Земскова О.В. Сучасні підходи до лікування вестибулярних шваном у хворих при нейрофіброматозі II типу з застосуванням радіохірургії / О.В. Земскова, О.Ю. Чувашова // Український нейрохірургічний журнал. – 2014. – № 3. – С. 66–71. – Режим доступу : URL : http://theunj.org/article/view/47497
Земскова О.В. Роль радиохирургии в комбинированном лечении вестибулярных шванном больших размеров / О.В. Земскова // Український нейрохірургічний журнал. – 2015. – № 2. – С. 64–69. – Режим доступа : URL : http://theunj.org/article/view/45300
The changing face of acoustic neuroma management in the USA: Analysis of the 1998 and 2008 patient surveys from the acoustic neuroma association / Patel Jaymin Patel, Rohit Vasan, Harry van Loveren, Katheryne Downes, Siviero Agazzi // Br. J. Neurosurgery. – 2014. – Vol. 28, № 1 – P. 20–24.
Results for local control and functional outcome after linac-based image-guided stereotactic radiosurgery in 190 patients with vestibular schwannoma / H. Badakhshi, R. Graf, D. Synowitz et al. // J. Radiat. Res. – 2013. – Vol. 55, № 2. – P. 228–292.
Iwai Y. Surgery combined with radiosurgery of large acoustic neuromas // Y. Iwai, K. Yamanaka, T. Ishiguro // Surg. Neural. – 2003. – Vol. 59. – P. 283–291.