Keywords
IL-15
osteopontin
myocardium disfunction
How to Cite
Abstract
The article contains results of a study of the content of osteopontin and IL-15 in hypertensive patients, revealed a relationship between them. The dependence of the reduction of systolic blood pressure and increased heart rate level of the concentration of osteopontin is established and proven link of high content of osteopontin in the blood plasma with poor left ventricular filling in early and late diastole.The possibility of participation of osteopontin in the formation of myocardial dysfunctionis discussed. It is recommended to determine the level of osteopontin in the blood plasma of patients with HD, and that helps to improve the early diagnosis of the risk of myocardial dysfunction and it's development.References
Основні показники інвалідності та діяльності медико-соціальних експертних комісій України за 2015 рік. Аналітично-інформаційний довідник / А.В. Іпатов, О.М. Мороз, В.А. Голик та ін. – Дніпропетровськ: Роял-Принт, 2016. – 157 с.
Peculiarities of myocardium remodeling in patients with ischemic heart disease and arterial hypertension / N.P. Potekhin, Iu.A. Rozhnov, F.A. Orlov et al. // Voen Med Zh. – 2011. – № 332 (2). – P. 30–37.
Samak M. Cardiac Hypertrophy: An Introduction to Molecular and Cellular Basis / M. Samak, J. Fatullayev, A. Sabashnikov // Med. Sci. Monit. Basic Res. – 2016. – Vol. 22. – P. 75–79.
Sinha S. Vascular calcification: lessons from scientific models / S. Sinha, H. Eddington, P.A. Kalra // J. Ren. Care. – 2009. – Vol. 35 – P. 51–56.
Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival / D.T. Denhardt, M. Noda, A.W. O’Regan et al. // J. Clin. Invest. – 2001. – Vol. 107. – P. 1055–1061.
Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host / G. Szalay, M. Sauter, M. Haberland et al. // Circ Res. – 2009. – Vol. 104 (7). – P. 851–859.
Pro- and anti-inflammatory cytokines in post-infarction left ventricular remodeling / S. Zarrouk-Mahjoub, M. Zaghdoudi, Z. Amira et al. // Int. J. Cardiol. – 2016. – № 221. – P. 632–636.
Nielsen A.R. The biological roles of exercise-induced cytokines: IL-6, IL-8, and IL-15 / A.R. Nielsen, B.K. Pedersen // Appl. Physiol. Nutr. Metab. – 2007. – Vol. 32(5) – P. 833–839.
Cho H.J. Osteopontin: a multifunctional protein at the crossroads of inflammation, atherosclerosis, and vascular calcification / H.J. Cho, H.S. Kim // Curr. Atheroscler. Rep. – 2009. – Vol. 11 (3). – P. 206–213.
Osteopontin plasma level are elevated in patients with chronic heart failure in relation to clinical severity and cytokine expression / S. Del Ry, M. Maltini, R. Poletti et al. // Eur. J. Heart Failure (Suppl. 1). – 2004. – Vol. 3. – P. 23.