Ключові слова
регуляторні Т-лімфоцити
клітини-супресори мієлоїдного походження
протипухлинний імунітет
Як цитувати
Анотація
Обговорюється проблема імунорегуляторних механізмів при пухлинному рості. Головна увага приділяється участі в ангіогенезі клітин супресорів різного походження: Т-регуляторних (Treg), клітин-супресорів мієлоїдного походження (MDSC). Розглянуті питання порушення регуляції імунозапальної відповіді, що призводять до різних патологічних станів, пов’язаних з ростом пухлин. Імовірно важливе значення при цьому має формування імунологічної толерантності, що запускається імунозапальним процессом, котрий не завершується. Висвітлено механізми, які пов’язують розвиток пухлин, толерантність і хронічну запальну реакцію, а також можливу регулюючу роль ряду лікарських речовин у цих процесах.Посилання
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