Keywords
alloxan
acid-releasing renal function
How to Cite
Abstract
The results of the study of acid-releasing renal function of rats with alloxan-induced experimental diabetes mellitus (EDM) of different duration allow the conclusion that the renal mechanisms of acid release in EDM function in an active adaptive mode with the involvement of maximal reserve potential in response to hyperglycemia-induced metabolic processes, accentuating the exceptional role of the kidneys in maintaining acid-base balance in diabetes mellitus. The initial stages of alloxan-induced EDM are accompanied by the extrarenal intensification of acid release, associated with enhanced inflow of non-volatile acids to the ultrafiltrate due to metabolic processes inherent to diabetes. Overload of compensatory-functional mechanisms of acid excretion leads to initiation of tubular maladaptation processes in the kidneys, which are manifested by functional insufficiency of sodium-hydrogen antitransport and sodium-dependent mechanisms of urine acidification with subsequent violation of proximal and distal acidification mechanisms, disruption of the compensatory capacity of the kidneys to regulate the acid-base status of the body.
Keywords: experimental diabetes mellitus, alloxan, acid-releasing renal function.
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