Vol 71 No 2 (2016), Proceedings of the VII National Congress of Pathophysiologists of Ukraine

Vol 71 No 2 (2016)

Dynamics of the morphofunctional changes of the offspring-rats’ pancreases resulting from an action of the unbalanced feeding

Proceedings of the VII National Congress of Pathophysiologists of Ukraine

Published August 25, 2020

O.V. Nikolayeva⁺⁻
O.O. Pavlova⁺⁻
V.A. Sirenko⁺⁻
M.V. Kovaltsova⁺⁻
I.O. Sulhdost⁺⁻

O.V. Nikolayeva

Kharkov National Medical University

O.O. Pavlova

Kharkov National Medical University

V.A. Sirenko

Kharkov National Medical University

M.V. Kovaltsova

Kharkov National Medical University

I.O. Sulhdost

Kharkov National Medical University

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Keywords

hyper- and hypocaloric diet
morphology and function of pancreas
offspring-rats’
cytokines

How to Cite

Nikolayeva, O., Pavlova, O., Sirenko, V., Kovaltsova, M., & Sulhdost, I. (2020). Dynamics of the morphofunctional changes of the offspring-rats’ pancreases resulting from an action of the unbalanced feeding. Experimental and Clinical Medicine, 71(2), 138-142. Retrieved from https://ecm.knmu.edu.ua/article/view/680

Abstract

The pancreas of offspring-rats’ that was born rats treated with unbalanced feeding revealed morphological changes: increased parenchymal area, acini and islets of Langerhans from babe-rats’ was born of pregnant rats treated with hypercaloric diet; reduced parenchymal area, acini and islets of Langerhans from babe-rats’ was born of pregnant rats treated with hypocaloric diet; the offspring-rats’ all groups have immaturity parenchymal area, edema, fibrosis and lipomatosis stroma, its inflammatory infiltration, degenerative changes in the nuclei and cytoplasm exocrine and endocrine cells; young rats also presented pro-inflammatory and anti-inflammatory cytokines imbalance with marker cytokine Th1-lymphocytes (interleukin-12) domination. Such morphological changes of the pancreas of animals suggest that unbalanced feeding in pregnant rats is a significant risk factor for chronic diseases of the pancreas in their rats-progeny

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