Influence of polymorphism rs1137101 of the leptin receptor gene on diabetes mellitus 2 types development
Vol 71 No 2 (2016), Proceedings of the VII National Congress of Pathophysiologists of Ukraine
Vol 71 No 2 (2016)

Influence of polymorphism rs1137101 of the leptin receptor gene on diabetes mellitus 2 types development

Proceedings of the VII National Congress of Pathophysiologists of Ukraine
Published August 19, 2020
S.V. Ziablitsev
Ukrainian Scientific and Practical Center for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine
P.A. Chernobrivtsev
Bogomolets national medical university
O.P. Chernobrivtsev
Ukrainian Scientific and Practical Center for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine
E.V. Antonov
Bogomolets national medical university
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Keywords

diabetes mellitus 2 types
leptin receptor gene
rs113710

How to Cite

Ziablitsev, S., Chernobrivtsev, P., Chernobrivtsev, O., & Antonov, E. (2020). Influence of polymorphism rs1137101 of the leptin receptor gene on diabetes mellitus 2 types development. Experimental and Clinical Medicine, 71(2), 86-89. Retrieved from https://ecm.knmu.edu.ua/article/view/655
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Abstract

It were studied of gene LEPR polymorphism rs1137101 role in diabetes mellitus 2 type development and his influences on the clinical and laboratory data, related to obesity for these patients. 103 patients are inspected, that had the clinically expressed complications. The analysis of polymorphic DNA-loci was carried out by the method of polymerase chain reaction in real time (TaqMan® SNP Genotyping Assay). Results showed that allelic polymorphism of rs1137101 (223Gln>Arg) had been associated with diabetes mellitus 2 types development: allele Gln promotes, while allele Arg reduces (OR=1,5; p=0,039) the risk of its development. Presence allele Gln for diabetic patients assists development of obesity and his displays, namely – to the higher values of body mass index and HOMA-IR, and also to the greater leptin and triglycerides blood levels on a background reduction of high-density lipoproteides maintenance.
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