Keywords
cytokines
tumor necrosis factor
interleukin-1
interleukin-1 receptor recombinant antagonist
dysregulative pathology
How to Cite
Abstract
The data are given reflecting experimental trial results that revealed both tumor necrosis factor-α (TNF) and interleukin-1 (IL-1) influences on different forms of kindling-induced chronic seizure syndrome. Cytokines modulating influence on seizures development and termination is discussed together with cytokines-induced changes of TNF and IL-1 levels in blood plasma and brain of kindled rats. Anticonvulsive effects were shown in conditions of picrotoxin kindling as the result of IL-1 receptors block. Authors concluded about the cytokines pathogenetic importance in epileptogenesis as well as about the chronic convulsive syndrome pathophysiologic mechanisms accenting on neural and immune systems pathological dysregulative integration development.References
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