Keywords
obesity
prediabetes
type 2 diabetes mellitus
nesfatin-1
dyslipidemia
How to Cite
Abstract
The study investigates the relationship of nesfatin-1 level with the lipid profile in prediabetes or type 2 diabetes mellitus of patients with essential hypertension and obesity. The study involved 57 patients with essential hypertension and obesity, which have been divided into groups depending on the state of carbohydrate profile. Nesfatin-1 Level was measured by enzyme immunoassay. Patients with essential hypertension had significantly higher level of this adipocytokine than healthy people. The positive correlations of nesfatin-1 level with glucose, insulin, HOMA-IR index, TG, VLDL cholesterol and a negative correlation with the levels of postprandial glucose, HDL cholesterol were established in patients with normoglycemia and prediabetes. The negative correlations of nesfatin-1 level with blood insulin and HOMA-IR index were found in patients with concomitant type 2 diabetes mellitus.References
Cardiovascular disease in Europe – epidemiological update / N. Townsend, M. Nichols, P. Scarborough et al. // Europ. Heart J. – 2015. – № 36. – P. 2696–2705.
Біловол О.М. Ожиріння в практиці кардіолога та ендокринолога / О.М. Біловол, О.М. Ковальова, С.С. Попова. – Тернопіль : ТДМУ, 2009. – 620 с.
Cardiometabolic risk profiles and carotid atherosclerosis in individuals with prediabetes identified by fasting glucose, postchallenge glucose, and hemoglobin A1c criteria / M. A. Marini, E. Succurro, E. Castaldo et al. // Diabetes Care. – 2012. – № 35. – P. 1144–1149.
Рекомендации по диабету, предиабету и сердечно-сосудистым заболеваниям. EASD/ESC Рабочая группа по диабету, предиабету и сердечно-сосудистым заболеваниям Европейского общества кардиологов (ESC) в сотрудничестве с Европейской ассоциацией по изучению диабета (EASD) // Российский кардиологический журнал. – 2014. – № 3 (107). – C. 7–61.
Ayada C. Nesfatin-1 and its effects on different systems / C. Ayada, Ü. Toru, Y. Korkut // Hippokratia. – 2015. – № 19 (1). – P. 4–10.
A novel adipocytokine? Nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats / H. Yamawaki, M. Takahashi, M. Mukohda et al. // Biochemical and Biophysical Research Communications. – 2012. – № 418 (4). –
Р. 676–681.
Yosten G.L. The anorexogenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist / G.L. Yosten, W.K. Samson // Am. J. Physiology. Regulatory, integrative and comparative physiology. – 2010. – № 298 (6). – Р. 1642–1647.
Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca(2+) influx through L-type channels in mouse islet beta-cells / M. Nakata, K. Manaka, S. Yamamoto et al. // Endocrine J. – 2011. – № 58. – P. 305–313.
Yosten G.L. Nesfatin-1 exerts cardiovascular actions in brain possible interaction with the central melanocortin system / G.L. Yosten, W.K. Samson // Am. J. Physiology. Regulatory, integrative and comparative physiology. – 2009. – № 297 (2). – Р. 330–336.
Peripheral effects of nesfatin-1 on glucose homeostasis / Z. Li, L. Gao,
H. Tang et al. // PLoS ONE. – 2013. – № 8 (8). – e71513.
Association of nesfatin-1 level with body composition, dietary intake and resting metabolic rate in obese and morbid obese subjects / K. Mirzaei, A. Hossein-nezhad, S.A. Keshavarz et al. // Diabetes Metab. Syndr. – 2015. – № 9 (4). – P. 292–298.