Effectiveness evaluation of progesterone therapy in women with threatened abortion based on clinical approach and single nucleotide polymorphism progesterone gene receptor rs590688
Vol 74 No 1 (2017), Obstetrics and Gynecology
Vol 74 No 1 (2017)

Effectiveness evaluation of progesterone therapy in women with threatened abortion based on clinical approach and single nucleotide polymorphism progesterone gene receptor rs590688

Obstetrics and Gynecology
Published July 30, 2020
О.P. Gnatko
Bogomolets national medical university
О.S. Kryvopustov
Bogomolets national medical university
PDF (Українська)

Keywords

threatened abortion
allelic polymorphism of progesterone receptor gene
progesterone treatment

How to Cite

GnatkoО., & Kryvopustov О. (2020). Effectiveness evaluation of progesterone therapy in women with threatened abortion based on clinical approach and single nucleotide polymorphism progesterone gene receptor rs590688. Experimental and Clinical Medicine, 74(1), 71-76. Retrieved from https://ecm.knmu.edu.ua/article/view/566
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Abstract

95 reproductive age women in 8–16 gestation weeks with a diagnosis of threatened abortion took part in this study. 67 women receiving progesterone therapy excluding SNP PGR rs590688. The main group consisted of 28 women which received progesterone therapy based on clinical and genetic approach – 15 women with genotype CG, GG and 13 women with genotype CC SNP PGR rs590688 (C/G). Patients with genotype CG, GG received oral natural micronized progesterone 300 mg daily and patients with genotype CC received oral natural micronized progesterone 600 mg daily. The study shows that progesterone treatment of women with threatened abortion which based on clinical and genetic approach reduces a treatment duration in 1,4 times (W = 841,5, p < 0,001), in 1,7 times faster disappear pain (χ2 = 10,89, p < 0,001) and in 1,9 times faster disappear bleeding (χ2 = 6,94, p < 0,05).
PDF (Українська)

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