Formation of systemic inflammation and therapeutic potential of purinergic inhibitors
Vol 75 No 2 (2017), Theoretical and Experimental Medicine
Vol 75 No 2 (2017)

Formation of systemic inflammation and therapeutic potential of purinergic inhibitors

Theoretical and Experimental Medicine
Published July 23, 2020
V.V. Ramazanov
Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine
Ye.L. Volovelskаya
Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine
E.Ye. Nipot
Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine
S.S. Yershov
Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine
N.A. Yershova
Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine
O.A. Shapkina
Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine
S.V. Rudenko
Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine
A.Ye. Ananina
Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine
V.A. Bondarenko
Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine
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Keywords

systemic inflammation
intestines
microorganisms
blood cells
purinergic mediators

How to Cite

Ramazanov, V., VolovelskаyaY., Nipot, E., Yershov, S., Yershova, N., Shapkina, O., Rudenko, S., Ananina, A., & Bondarenko, V. (2020). Formation of systemic inflammation and therapeutic potential of purinergic inhibitors. Experimental and Clinical Medicine, 75(2), 30-36. Retrieved from https://ecm.knmu.edu.ua/article/view/494
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Abstract

Systemic inflammation of the body may be infectious or non-infectious origin, and can occur with transfusion of red blood cells. Developing an effective therapeutic approach to control inflammation to prevent development of multiple organ failure and septic shock is a major task that can be resolved in experimental studies. In the last decade there has been a line of research associated with regulation of cellular metabolism, via purinergic signaling with the aim of balancing immune homeostasis. Likely, this direction will be adequate for the purpose of developing a new approach, which combined with traditional treatment could be an effective method of treatment of systemic inflammation.
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