Keywords
XRCC1
XRCC3
bronchopulmonary pathology
How to Cite
Abstract
The article presents the results of the investigation on the polymorphism of the DNA repair genes of in miners and workers of asbestos cement plants with occupational determined respiratory pathology. Purpose: to study the distribution of frequencies of genotypes of genes XRCC1 (rs25487) and XRCC3 (rs861539) in workers of harmful and dangerous industries for identifying markers of the risk of bronchopulmonary pathology. The real-time polymerase chain reaction was used to determine genotypes of DNA repair genes. As a result of the study it was established that the XRCC1•AA genotype is associated with the risk of bronchopulmonary pathology in the population of workers in asbestos-cement plants and coal miners of Ukraine. The protective role of the genotype XRCC1•GA in relation to the risk of developing bronchopulmonary system diseases in workers of asbestos-cement plants in Ukraine has been established.References
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