Comparative charcteristics of carbohydrate metabolism in patients with pulmonary tuberculosis depending on the presence or absence of bacterial excretion
PDF (Українська)

Keywords

pulmonary tuberculosis
firstly diagnosed tuberculosis
bacterial excretion
blood glucose
glycemic profile

How to Cite

Shvets, O., Shevchenko, O., & Veretelnyk, O. (2020). Comparative charcteristics of carbohydrate metabolism in patients with pulmonary tuberculosis depending on the presence or absence of bacterial excretion. Experimental and Clinical Medicine, 78(1), 95-100. Retrieved from https://ecm.knmu.edu.ua/article/view/382

Abstract

83 patients with firstly diagnosed pulmonary TB (FDTB) were examined. Group 1 consisted of 18 (21.9 %) patients with FDTB of lungs without bacterial excretion. Group 2 included 65 (78.3 %) patients with bacterial excretion. Age varied from 19 to 66 years, men prevailed. When comparing blood glucose values, it was found that in Group 1 they varied within 3.4 – 6.0 mmol/l, the average index was 4.6 mmol/l, and in Group 2 – from 3.4 to 9.0, an average of 5.6 mmol/l. It was confirmed that the differences in the average values of the fasting blood glucose level in patients with bacterial excretion and without bacterial excretion are statistically significant at p˂0.05 (the obtained value is p = 0.026). The findings indicate the effect of the severity of the tuberculosis process on the glycemic profile, possibly due to insulin resistance. Therefore, the study of insulin resistance markers is planned by the next stage of the work.
PDF (Українська)

References

World Health Organization. Global tuberculosis report (2016). WHO/HTM/TB/2016.13 Geneva, Switzerland: WHO.

Oni T., Youngblood E., Boulle A., McGrath N., Wilkinson R.J., Levitt N.S. (2015). Patterns of HIV, TB, and non-communicable disease multi-morbidity in peri-urban South Africa – a cross sectional study. BMC Infect. Dis. 15: 20. pmid:25595711

Slama K., Chiang C.Y., Enarson D.A., Hassmiller K., Fanning A., Gupta P. et al. (2007). Tobacco and tuberculosis: a qualitative systematic review and meta-analysis. Int J Tuberc. Lung. Dis. 11: 1049–1061. pid:17945060

Nathella Pavan Kumar, Vaithilingam V. Banurekha, Dina Nair, Rathinam Sridhar, Hardy Kornfeld, Thomas B. Nutman, Subash Babu (2014). Coincident Pre-diabetes is Associated with Dysregulated Cytokine Responses in Pulmonary. PLoS One. 9 (11). e112108.

Ottmani S.E., Murray M.B., Jeon C.Y., Baker M.A., Kapur A., Lönnroth K., Harries A.D. (2010). Consultation meeting on tuberculosis and diabetes mellitus: meeting summary and recommendations. Int. J. Tuberc. Lung. Dis. Dec; 14(12): 1513–1517.[PubMed]

Kapur A., Harries A.D. (2013). The double burden of diabetes and tuberculosis-public health implications. Diabetes Res. Clin. Pract. 101: 10–19.

Kaminskaya G.O., Abdullaev R.Y. (2014). Pathophysiologicheskie predposylki neblahopriiatnoho vliianiia sakharnogo diabetana techeniie tubrkulioza lehkih [Pathophysiological prerequisites for the adverse effect of diabetes on pulmonary tuberculosis]. Tuberculosis and Lung Diseases. 3: 5–11 [in Russian].

International Diabetes Federation. IDF Diabetes Atlas. 7th ed Brussels, Belgium: IDF, 2017. http://www.diabetesatlas.org/ Accessed May 2017

Li L., Lin Y., Mi F. et al. (2012). Screening of patients with tuberculosis for diabetes mellitus. Trop. Med. Int. Health. 17: 1294–1301.

Harries A.D., Kumar A.M.V., Satyanarayana S. et al. (2015). Diabetes mellitus and tuberculosis: programmatic management issues. Int. J. Tuberc. Lung. Dis. 19: 879–886. Doi:10.5588/ijtld.15.0069

Nakaz MOZ Ukrainy № 384 vid 09.06.06 «Pro zatverdzhennia Protokolu nadannia medychnoi dopomohy khvorym na tuberkuloz» [The order of the Ministry of Health of Ukraine No. 600 dated 22.10.08 «About solidification of the standard of medicinal care we apply for chemoradestination tuberculosis»] [in Ukrainian].

Nakaz MOZ Ukrainy № 385 vid 09.06.06 «Pro zatverdzhennia Instruktsii shchodo nadannia dopomohy khvorym na tuberkuloz» [The order of the Ministry of Health of Ukraine No. 385 dated 09.06.06 «About the solidification of the organization, we add to the tuberculosis»] [in Ukrainian].

Nakaz MOZ Ukrainy № 600 vid 22.10.08 «Pro zatverdzhennia standartu nadannia medychnoi dopomohy khvorym na khimiorezystentnyi tuberkuloz» [The order of the Ministry of Health of Ukraine No. 600 dated 22.10.08 «About solidification of the standard of medicinal care we apply to chemorreistant tuberculosis»] [in Ukrainian].

Nakaz MOZ Ukrainy № 620 vid 04.09.2014 ««Pro zatverdzhennia ta vprovadzhennia medyko-tekhnolohichnykh dokumentiv zi standartyzatsii medychnoi dopomohy pry tuberkulozi» [The order of the Ministry of Health of Ukraine No. 620 dated 04.09.14 «About solidification in the field of medical and technological documents in the standardization of medical care for tuberculosis»] [in Ukrainian].