Keywords
cornea
immunity
How to Cite
Abstract
The article presents data on the influence of mechanical non-penetrating corneal trauma on the indices of humoral and cellular immunity in rabbits’ blood. Experimental non-penetrating corneal trauma is accompanied by inhibition of humoral immunity factors in the early post-traumatic period with a maximum reduction in the 14th day of observation and marked violation of cellular immunity in the form of an imbalance in the subpopulation composition of T-lymphocytes with a predominant decrease in T-suppressors and a progressive increase in the immunoregulatory index. Keywords: mechanical non-penetrating trauma, cornea, immunity.References
Nedzvetckaia O.V. (2015). Neotlozhnaia pomoshch pri raneniiakh i kontuziiakh organa zreniia i ego pridatochnogo apparata (Lektciia-konspekt dlia vrachei neotlozhnoi pomoshchi, semeinykh vrachei, internov, vrachei-oftalmologov) [Emergency care at injuries and contusions of the organ of vision and its adnexa (Lecture-summary for physicians of emergency care, family doctors, interns, ophthalmologists)]. Meditcina neotlozhnykh sostoianii – Medicine of urgent states. 4 (67): 9–21 [in Russian].
Kasymov F.O., Kulikov V.S., Nikolaenko V.P., Zumbulidze N.G. (2015). Mekhanicheskaia travma organa zreniia [Mechanical trauma of the organ of vision: Textbook. allowance]. GBOU VPO SZGMU im. I.I. Mechnikova: 51 [in Russian].
Chudniavtceva N.A. (2012). Implantatciia miagkoi zadnekamernoi IOL pri narushenii kapsulnoi podderzhki u bolnykh s travmaticheskim povrezhdeniem khrustalika i steklovidnogo tela [Implantation of a soft posterior chamber IOL with capsular support disruption in patients with traumatic damage of the lens and vitreous]. Oftalmologicheskii zhurnal – Ophthalmological journal. 6: 124–127 [in Russian].
Polianskaia N.K. (2008). Epikeratoamnioplastika v lechenii bolnykh tiazhelymi destruktivnymi zabolevaniiami i travmami rogovitcy [Epikeratoamnioplasty in the treatment of patients with severe destructive diseases and traumas of the cornea]. Sovremennye aspekty kliniki, diagnostiki i lecheniia glaznykh boleznei: mezhdunar. nauch. konf., posviashch. 100-letiiu so dnia rozhdeniia akad. N.A. Puchkovskoi: 47–48 [in Russian].
Aksenova S.V. (2017). Dinamika nekotorykh pokazatelei immuniteta u bolnykh s gerpeticheskim keratitom na fone kompleksnoi s emoksipinom terapii [Dynamics of some indices of immunity in patients with herpetic keratitis against the background of complex therapy with emoxipin]. Nauchnyi meditcinskii vestnik – Scientific medical bulletin. 1(7): 18–26 [in Russian].
Chuprina V.V. (2010). Izmeneniia funktcii immunnoi sistemy i ikh korrektciia u postradavshikh s pronikaiushchim raneniem glaza [Changes in the functions of the immune system and their correction in victims with a penetrating wound of the eye]: avtoref. diss. ... k.m.n. Perm.: 25 [in Russian].
Golubov K.E. (2008). Klinicheskaia effektivnost primeneniia imunofana pri kontuzionnoi travme organa zreniia [Клиническая эффективность применения иммунофана при контузионной травме органа зрения]. Materialy Mizhnarodnoi naukovoi konferentsii, prysviachenoi 100-richchiu z dnia narodzhennia akademika N.O. Puchkivskoi «Suchasni aspekty kliniky, diahnostyky ta likuvannia ochnykh khvorob» 29-30 travnia 2008 roku. Odesa: 200 [in Russian].
European convention for the protection of vertebrate animals used for experimental and other scientific purposes. (1986). Council of Europe. Strasbourg. 123: 52.
Kozhemiakin Yu.M. (2002). Naukovo-praktychni rekomendatsii z utrymannia laboratornykh tvaryn ta roboty z nymy [Науково-практичні рекомендації з утримання лабораторних тварин та роботи з ними]. 155 [in Ukrainian].
Bunders M. (2005). Аge-related standards for total lymphocyte, CD4+ and CD8+ T cell counts in children born in Europe. Pediatr. Infect. Dis. J. 24, 7: 595-600.
Kuznetsova L.V., Babadzhan V.D.,. Kharchenko N.V. (2013). Imunolohiia: pidruchnyk [Immunology: textbook]. Vinnitsia: Merkiuri Podillia. 565 [in Ukrainian].
Kadyrov R.Z., Gareev E.M., Iakovleva V.G., Kurchatova N.N., Iusupova R.Sh., Primov R.E. (2012). Immunologicheskaia kharakteristika patcientov s razlichnoi patologiei rogovitcy pri provedenii posloinoi keratoplastiki s primeneniem biomateriala «alloplant» [Иммунологическая характеристика пациентов с различной патологией роговицы при проведении послойной кератопластики с применением биоматериала «аллоплант»]. Meditcinskaia immunologiia – Medical immunology. 14 (6): 513–518 [in Russian].
Kasimov E.M., Zargarli I.A., Namazova I.K., Medzhidova S.R. (2011). Sravnitelnaia otcenka immunologicheskoi reaktivnosti pri sochetannoi travme glaza. Oftalmologiia. 3(7): 50–55 [in Russian].
Kozariichuk N.Ia. (2016). Sovremennye dannye o mekhanizmakh immunnoi disfunktcii pri povrezhdenii perednego otdela glaznogo iabloka (obzor literatury). Klіnіchna ta eksperimentalna patologіia. XV, 2 (56), 1: 210–214 [in Russian].
Kopaeva V.G. (Eds.). (2012). Glaznyie bolezni. Osnovy oftalmologii: Uchebnik [Eye diseases. Basics of Ophthalmology: A Textbook]. 560 [in Russian].
Turchin N.V. (2015). Dinamika pokazatelei kletochnogo immuniteta krovi i vodianistoi vlagi pri eksperimentalnoi mekhanicheskoi nepronikaiushchei travme rogovitcy [Dynamics of cellular immunity of blood and watery moisture in experimental mechanical non-penetrating trauma of the cornea]. Oftalmologiia. Vostochnaia Evropa – Ophthalmology. Eastern Europe. 4 (27): 35–41 [in Russian].