Keywords
cardiomyoplasty
heart failure
refractory angina
How to Cite
Abstract
The aim of the study was to optimize the technique of cellular cardiomyoplasty in patients with refractory angina. The results of treatment of 75 patients with refractory angina who were hospitalized in the Emergency and Reconstructive Cardiac Surgery Department of the "V. Gusak Institute of Emergency and Reconstructive Surgery of NAMS of Ukraine" from 2007 to 2013 were analyzed. The intramyocardial implantation of autologous mesenchymal bone marrow stem cells in patients with chronic coronary heart disease and severe left ventricular failure is a safe method that can improve clinical data and prognosis. This method can be used as the first line of coronary heart disease treatment to prepare a patient for aortocoronary bypass. The injection of bone marrow stem cells in ischemic segments improves perfusion without induction of additional myocardial scarring. Unfortunately, currently there is no alternative to adequate therapy of patients with cardiac insufficiency, which is possessed of a minimal number of negative effects on one hand and could give patients a real chance for a positive effect of therapy on other one.
Keywords: stem cells, cardiomyoplasty, heart failure, refractory angina.
References
Voronkov L.G., Berezin O.Je., Zharinova V.Ju., Zhebel V.M., Koval O.A., Rudyk Ju.S., … & Celujko V.J. (2019). Biolohichni markery ta yikh zastosuvannya pry sertseviy nedostatnosti. Konsensus Vseukrayinskoyi asotsiatsiyi kardiolohiv Ukrayiny, Vseukrayinskoyi asotsiatsiyi fakhivtsiv iz sertsevoyi nedostatnosti ta Ukrayinskoyi asotsiatsiyi fakhivtsiv z nevidkladnoyi kardiolohiyi [Biological markers and their use in heart failure. Consensus of the All-Ukrainian Association of Cardiologists of Ukraine, the All-Ukrainian Association of Specialists in Heart Failure and the Ukrainian Association of Specialists in Emergency Cardiology]. Ukrayinskyy kardiolohichnyy zhurnal - Ukrainian Journal of Cardiology, vol. 26, is. 2, pp. 19-30 [in Ukrainian].
Nikonenko A.S., Molodan A.V., & Ivashchuk V.A. (2015). Otsenka deformatsionnykh svoystv miokarda u bol'nykh ishemicheskoy bolezn'yu serdtsa s vyrazhennoy dilatatsiyey polosti levogo zheludochka, oslozhnennoy serdechnoy nedostatochnost'yu [Evaluation of the deformation properties of the myocardium in patients with ischemic heart disease with severe dilatation of the left ventricular cavity, complicated by heart failure]. Visnyk sertsevo-sudynnoyi khirurhiyi - Bulletin of Cardiovascular Surgery, No.23, pp.135–139 [in russian].
Gabrielyan A.V., Smorzhevsky V.J., Onishchenko V.F., Lukach P.M., Belejovych V.V., & Domansky T.M. (2009). Koroname shuntuvannya u khvorykh IKHS z khronichnoyu sertsevoyu nedostatnistyu [Coronary artery bypass grafting in patients with coronary heart disease with chronic heart failure]. Shchorichnyk naukovykh prats Asotsiatsiyi sertsevo-sudynnykh khirurhiv Ukrayiny -Yearbook of scientific works of the Association of Cardiovascular Surgeons of Ukraine, No.17, pp. 103–107 [in Ukrainian].
Ponikowski R., Anker S.D., AlHabib K.F., et al. (2014). Heart failure: preventing disease and death worldwide. ESC Heart Failure, vol. 1, No.1, pp. 4–25.
Alba A.C., Foroutan F., Duero Posada J., et al. (2018). Implantable cardiac defibrillator and mortality in non-ischaemic cardiomyopathy: an updated meta-analysis. Heart, vol. 104, No.3, pp. 230–236.
Nanayakkara S., Patel H.C., Kaye D.M. (2018). Hospitalisation in Patients with Heart Failure With Preserved Ejection Fraction. Clin Med Insights Cardiol, vol. 12, pp. 1179–1189.
Krykunov O.A., Rudenko K.V., Rusnak A.O., Luchynec O.F., Burjak R.V., Shapovalova V.V. (2015). Kompleksnyy pidkhid do likuvannya khvorykh na dylatatsiynu kardiomiopatiyu [A comprehensive approach to the treatment of patients with dilated cardiomyopathy], Visnyk sertsevo-sudynnoyi khirurhiyi - Bulletin of Cardiovascular Surgery, No.23, pp. 77–82 [in Ukrainian],
Blair A. (2018). The Use of Left Ventricular Assist Devices in End-Stage Heart Failure. Crit Care Nurs Q., vol. 41, No.4, pp. 376–382.
Nishimura S., Izumi C., Himura Y., KurodaM., Amano M. et al. (2018). Very long-term follow-up data of non-ischemic idiopathic dilated cardiomyopathy after beta-blocker therapy: recurrence of left ventricular dysfunction and predictive value of 1231-metaiodobenzylguanidine scintigraphy. Heart Vessels, 34(2), pp. 259–267. DOI: 10.1007/s00380-018-1245-y.
Kanda P., & Davis D. (2017). Cellular mechanisms underlying cardiac engraftment of stem cells. Expert Opinion on Biological Therapy, vol. 17, is. 9, pp. 1127–1143. DOI: 10.1080/14712598.2017.1346080.
Gabrielian A.V., Salyutin R.V., Yakushev A.V., Onishchenko V.F., Shablyy V.M., Domansky T.M., … & Myronyuk O.I. (2014). Suchasni pidkhody ta metodyky transplantatsiyi stovburovykh klityn khvorym z terminalnoyu stadiyeyu sertsevoyi nedostatnosti [Modem approaches and methods of stem cell transplantation in patients with end-stage heart failure]. Kardiokhirurhiya ta interventsiyna kardiolohiya - Cardiac surgery and interventional cardiology, vol. 1, No.6, pp. 8–12 [in Ukrainian].
Gabrielian A.V. (2014). Sovremennyye metody khimrgicheskogo lecheniya refraktemoy serdechnoy nedostatochnosti pri ishemicheskoy bolezni serdtsa [Modem methods of surgical treatment of refractory heart failure in ischemic heart disease]. Klinichna khirurgiya- Clinical surgery, No.1.2.(854), pp. 52–55 [in russian].
Gabrielyan A.V., Smorzhevsky V.J., Domansky T.N., Onishchenko V.F. (2011). Dzherela stovburovykh klityn dlya likuvannya khvorykh z pomshenoyu funktsiyeyu skorochennya miokarda [Sources of stem cells for the treatment of patients with impaired myocardial contraction]. Sertse і sudyny - Heart and vessels, vol.3, No.35, pp. 89–92 [in Ukrainian].