Keywords
VDR gene polymorphism
coronary heart disease
chronic obstructive pulmonary disease
periodontal disease
How to Cite
Abstract
This paper presents the results of the study of the incidence and nature of periodontal diseases in cases of the VDR gene Taq1 polymorphism in patients with chronic obstructive pulmonary disease combined with coronary heart disease. It has been established that periodontal diseases are of multifactorial nature and have a genetic and phenotypic dependence. 144 patients were examined (115 people with chronic obstructive pulmonary disease combined with coronary heart disease and 29 patients with coronary heart disease). Complementary to clinical dental examination, there has been performed genotyping of T/C Taq1 T>t polymorphism (rs 731236) of the VDR gene using a polymerase chain reaction method. It has been noted that patients with coronary heart disease tend to have the TT genotype homozygotes more often if compared to the mutant C allele genotype. However, the primary group showed no differences between the TT and CC genotypes. It has been discovered that the patients of the primary group tend to have periodontal disease more often if compared to the group of patients with coronary heart disease. These results prove the need for future studies to develop methods for correction.References
Van der Beil Peter. (2014). The relationship between periodontal diseases and the cardiovascular system. Problems of Dentistry, № 6, pp. 4–8.
Amano Y., Komiyama K., Makishima M. (2009). Vitamin D and periodontal disease. Journal Oral Science, vol. 51 (1), рр. 11–20.
Gunes S., Sumer A.P., Keles G.C. et al. (2008). Analysis of vitamin D receptor gene polymorphisms in patients with chronic periodontitis. Indian J. Med. Res., vol. 127 (1). pp. 58–64.
Hennig B.J., Parkhill J.M., Chapple I.L., Heasman P.A., Taylor J.J. (1999). Association of a vitamin D receptor gene polymorphism with localized early-onset periodontal diseases. Journal of Periodontology, vol. 70 (9), рр. 1032–1038.
Yoichi Tachi. Hitomi Shimpuku, Yasuhiro Nosaka, Tatsuya Kawamura, Mitsuko Shinohara, Masatoshi Ueda et al. (2001). Association of vitamin D receptor gene polymorphism with periodontal diseases in Japanese and Chinese. Nucleic Acids Research Supplement, № 1, pp. 111–112.
Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease (GOLD): Updated 2016. Retrieved from www.goldcopd.com.
Bayram B., Sayn B., Tьrkoglu Z. et al. (2011). An Investigation into the Relationship Between Taq1 and Apa1Polymorphisms of the Vitamin D Receptor Gene and the Development of Osteoarthritis. Turk. J. Rheumatol. – vol. 26 (4), –pp. 303–307.