Some relationships in the formation of arterial hypertension in patients with chronic obstructive pulmonarydiseases and influence of calcium antogonists at this process
Vol 87 No 2 (2020), Therapy
Vol 87 No 2 (2020)

Some relationships in the formation of arterial hypertension in patients with chronic obstructive pulmonarydiseases and influence of calcium antogonists at this process

Therapy
https://doi.org/10.35339/ekm.2020.87.02.03
Published October 1, 2020
V.M. Pogorelov
Kharkiv National Medical University, Kharkiv, Ukraine
https://orcid.org/0000-0002-5980-8130
N.D. Telegina
Kharkiv National Medical University, Kharkiv, Ukraine
V.V. Brek
Kharkiv National Medical University, Kharkiv, Ukraine
https://orcid.org/0000-0001-5528-8337
E.P. Maslova
Kharkiv National Medical University, Kharkiv, Ukraine
https://orcid.org/0000-0001-5157-3704
K.O. Chernonos
Kharkiv National Medical University, Kharkiv, Ukraine
https://orcid.org/0000-0003-0168-0717
PDF (Українська)

Keywords

chronic obstructive pulmonary disease
arterial hypertension
endothelial dysfunction
pentoxifylline and felodipine

How to Cite

Pogorelov, V., Telegina, N., Brek, V., Maslova, E., & Chernonos , K. (2020). Some relationships in the formation of arterial hypertension in patients with chronic obstructive pulmonarydiseases and influence of calcium antogonists at this process. Experimental and Clinical Medicine, 87(2), 21-26. https://doi.org/10.35339/ekm.2020.87.02.03
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX

Abstract

Intracardiac and central hemodynamics, interleukins, nitric oxide levels and nitric oxide synthase, endothelin-1 were studied. We observed 63 patients with chronic obstructive pulmonary disease with hypertension who received combination therapy with pentoxifylline, of whom 32 patients (main group) included felodipine in addition to this therapy. After treatment, there was a decrease of pressure in pulmonary artery and main vessels, which was accompanied by improvement of clinical manifestations of the disease, hemodynamics, increased activity of nitric oxide synthase and reduction of endothelin-1, interleukin-1β, interleukin-6 and tumor necrosis factor. Positive clinical laboratory dynamics were more pronounced in the main observation group than in the comparison one.

Keywords: chronic obstructive pulmonary disease, arterial hypertension, endothelial dysfunction, pentoxifylline and felodipine.

https://doi.org/10.35339/ekm.2020.87.02.03
PDF (Українська)

References

Chatteijee, A., Black, S.M., & Catravas, J.D. (2008). Endothelial nitric oxide (NO) and its pathophysiologic regulation. Vascul Pharmacol, 49(4-6), p. 134-140, DOI: 10.1016/j.vph.2008.06.008.

Katerenchuk, I.P, & Tsyhanenko, I.V. (2017). Endotelialna dysfunktsiia ta kardiovaskuliamyi ryzyk. Prychyny, mekhanizmy rozvytku, klinichni proiavy, likuvannia і profilaktyka [Endothelial dysfunction and cardiovascular risk. Causes, mechanisms of development, clinical manifestations, treatment and prevention]. Kyiv: Vydavnychyi dim Medknyha, 256 p. [in Ukrainian].

Testa, U., Pannitteri, G., & Condorelli, G.L. (2008). Vascular endothelial growth factors in cardiovascular medicine. J. Cardiovasc Med., No.9, pp. 1190-1221, DOI: 10.2459/JCM.0b013e3283117d37.

Polivoda, S.N. (2009). Endotelialnayadisfunktsiyaprigipertonicheskoybolezni: patofiziologicheskie mekhanizmi formirovaniya [Endothelial dysfunction in hypertension: pathophysiological mechanisms of formation]. Arterialnaya gipertenziya - Arterial hypertension, 5(7), p. 29-33 [in russian].

Kryvenko, V.V. (2013). Osnovni kardiovaskuliami chynnyky vplyvunapokaznykyyakosti zhyttiau khvorykh z poiednanym perebihom khronichnoho obstruktyvnoho zakhvoriuvannia lehen ta hipertonichnoiu khvoroboiu [Major cardiovascular factors of influence on quality of life indicators in patients with a combined course of chronic obstructive pulmonary disease and hypertension]. Visnykproblem biolohii і medytsyny-Bulletin ofproblems ofbiology and medicine, 2(1(99)), p. 117-120 [in Ukrainian].

Mostovoi, Yu.M., & Rasputina, L.V. (2010). Khronichne obstruktyvne zakhvoriuvannialehen ta arterialna hipertenziia: osoblyvosti klinichnoho perebihu, taktyka likuvannia [Chronic obstructive pulmonary disease and arterial hypertension: features of clinical course, treatment tactics]. Ukrainian Pulmonology Journal, vol. 1, p. 23. Retrieved from: http://www.ifp.kiev.ua/doc/joumals/upj/10/pdfl0-1/23.pdf [in Ukrainian].

Chen, H., De Marco, T., Kobashigawa, E.A., Katz, RR, Chang, V.W., & Blanc, RD. (2011). Comparison of cardiac and pulmonary-specific guabity-of-life measures in pulmonary arterial hypertension. Eur. Respir. J., vol. 38, pp. 608-616, DOI: 10.1183/09031936.00161410.

Lang, I.M., Dorfmuller, R, & Vonk Noordegraaf, A. (2016). The pathobiology of chronic thromboembolic pulmonary hypertension. Ann. Am. Thorac. Soc., vol. 13 suppl 3, pp. 215-221, DOI: 10.1513/AnnalsATS.201509-620AS.

Dokazannaya effektivnost pentoksifillina v lechenii patsiyentov s tserebrovaskulyamoy patologiyey (po materialam: M.F. McCarty, J.H. O'Keefe, J.J. DiNicolantonio. Pentoxifylline for vascular health: a brief review of the literature. Open Heart 2016; 3: e000365) [Proven effectiveness of pentoxifylline in the treatment of patients with cerebrovascular pathology (based on materials: M.R McCarty, J.H. O'Keefe, J.J. DiNicolantonio. Pentoxifylline for vascular health: a brief review of the literature. Open Heart 2016; 3: e000365)]. (2017). Praklichna angiologiya PracticalAngiology. 1(76), pp. 42-46 [in russian].

Kovalova, O.M., Demydenko, H.V., & Horbach, T.V. (2007). Diahnostyka endotelialnoi funktsii – otsinka vazoaktyvnoho pulu oksydu azotu [Diagnosis of endothelial function – assessment of the vasoactive pool of nitric oxide]. Ministerstvo okhorony zdorovia Ukrainy. Ukr. tsentr nauk. medychnoi informatsii tapatentno-litsenziinoi roboty. Kyiv, 16 p. [in Ukrainian].