Regional features of actinides deposition in kidney stones of patients with urolithiasis
Vol 91 No 2 (2022), Urology, Andrology and Nephrology
Vol 91 No 2 (2022)

Regional features of actinides deposition in kidney stones of patients with urolithiasis

Urology, Andrology and Nephrology
https://doi.org/10.35339/ekm.2022.91.2.kld
Published June 30, 2022
S.M. Kolupayev
Kharkiv National Medical University, Kharkiv, Ukraine
http://orcid.org/0000-0001-7128-4555
V.M. Lisovyi
Kharkiv National Medical University, Kharkiv, Ukraine
http://orcid.org/0000-0001-8149-1232
M.P. Dikiy
National Science Center "Kharkiv Institute of Physics and Technology", Kharkiv, Ukraine
http://orcid.org/0000-0002-1289-625X
O.P. Medvedeva
National Science Center "Kharkiv Institute of Physics and Technology", Kharkiv, Ukraine
http://orcid.org/0000-0003-4765-5162
M.I. Cherniak
Kharkiv National Medical University, Kharkiv, Ukraine
http://orcid.org/0000-0002-7425-659X
PDF (Українська)

Keywords

uranium
Kharkiv region
uroliths

How to Cite

Kolupayev , S., Lisovyi , V., Dikiy , M., Medvedeva , O., & Cherniak , M. (2022). Regional features of actinides deposition in kidney stones of patients with urolithiasis. Experimental and Clinical Medicine, 91(2), 33-37. https://doi.org/10.35339/ekm.2022.91.2.kld
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX

Abstract

Uranium is one of the most studied actinoids, widely used in the nuclear industry, and can accumulate in drinking water, soil, plants, and calcium-containing body tissues. The purpose of the work was to investigate the presence of uranium isotopes 235U and 238U in the composition of kidney stones of patients with urolithiasis living in the Kharkiv region. The content of 235U and 238U was investigated in samples of kidney stones obtained as a result of minimally invasive surgical interventions for urolithiasis in 57 patients, residents of the Kharkiv region, using gamma activation analysis on a linear electron accelerator. According to the results of our research 235U and 238U were detected in 13 (27%) samples of calcium-containing kidney stones, the mineral composition of which was represented by calcium oxalate monohydrate (wevellite), calcium oxalate dihydrate (weddellite) and phosphate-calcium compounds (apatite, hydroxyapatite, fluorapatite, carbonateapatite). The content of the above-mentioned isotopes in the composition of kidney stones was equal to ~ 1 ppm (mkg/g). We concluded that timely treatment of urolithiasis will help minimize the toxic effect of uranium on kidney structures.

Keywords: uranium, Kharkiv region, uroliths.

https://doi.org/10.35339/ekm.2022.91.2.kld
PDF (Українська)

References

Suhard D, Tessier C, Manens L, Rebiere F, Tack K, Agarande M, Gueguen Y. Intracellular uranium distribution: Comparison of cryogenic fixation versus chemical fixation methods for SIMS analysis. Microsc Res Tech. 2018;81(8):855-64. DOI: 10.1002/jemt.23047. PMID: 29737608.

Sridhara GR, Sridhar KN, Manjunatha HC, Ramalingam HB. Systematic study of the α decay properties of actinides. Pramana. 2019;93(5):14. DOI: 10.1007/s12043-019-1845-9.

Durakovic A. Medical effects of internal contamination with actinides: further controversy on depleted uranium and radioactive warfare. Environ Health Prev Med. 2016;21(3):111-7. DOI: 10.1007/s12199-016-0524-4. PMID: 27002520.

Gao N, Huang Z, Liu H, Hou J, Liu X. Advances on the toxicity of uranium to different organisms. Chemosphere. 2019;237:124548. DOI: 10.1016/j.chemosphere.2019.124548. PMID: 31549660.

Reynard B, Balter V. Trace elements and their isotopes in bones and teeth. Palaeogeography, Palaeoclimatology, Palaeoecology. 2014;416:4-16. DOI: 10.1016/j.palaeo.2014.07.038.

Hummadi SS. Determination of uranium concentration in teeth female samples using fission tracks in CR-39 from dierent countries. J. lNahrain Univer. 2010;13(4):127-31. Available at: https://www.anjs.edu.iq/index.php/anjs/article/view/991

Singh P, Enders FT, Vaughan LE, et al. Stone Composition Among First-Time Symptomatic Kidney Stone Formers in the Community. Mayo Clin Proc. 2015;90(10):1356-65. DOI:10.1016/j.mayocp.2015.07.016. PMID: 26349951.

Dikiy NP, Dovbnya AN, Lyashko YuV, Medvedev DV, Medvedeva EP, Botova ID, et al. Radionuclide accumulation by objects of ecosystem. Problems of atomic science and technology (PAST). 2014;5:45-9. Available at: https://vant.kipt.kharkov.ua/ARTICLE/VANT_2014_5/article_2014_5_45.pdf

Khan SR, Pearle MS, Robertson WG, Gambaro G, Canales BK, Doizi S, et al. Kidney stones. Nat Rev Dis Primers. 2016;2:16008. DOI: 10.1038/nrdp.2016.8. PMID: 27188687.

Taylor DM, Taylor SK. Environmental uranium and human health. Rev Environ Health. 1997;12(3):147-57. DOI: 10.1515/reveh.1997.12.3.147. PMID: 9406286.

Gueguen Y, Rouas C. New data on uranium nephrotoxicity. Radioprotection. 2012;47:345-59. DOI: 10.1051/radiopro/2012015. PMID: 35457214.

Vicente-Vicente L, Quiros Y, Pérez-Barriocanal F, López-Novoa JM, López-Hernández FJ, Morales AI. Nephrotoxicity of uranium: pathophysiological, diagnostic and therapeutic perspectives. Toxicol Sci. 2010;118(2):324-47. DOI: 10.1093/toxsci/kfq178. PMID: 20554698.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.