Keywords
obesity
body fat composition
physical training
healthy diet
How to Cite
Abstract
The article is devoted to the peculiarities of endothelial dysfunction of women with different types of obesity before and after correction of body composition. The article is devoted to the peculiarities of endothelial dysfunction in women with different types of obesity before and after correction of body composition. Obesity as a polygenic disease is a progressive problem of society. Numerous studies of recent decades have been devoted to the influence of excessive weight on human health, which indicate that obesity is an independent risk factor for cardiovascular disease, characterized by high mortality. The degree of cardiovascular risk in obesity depends on the distribution of adipose tissue, and hence on the normal functioning of the endothelium, since endothelial dysfunction is one of the first triggers of cardiovascular disease. The author noted that endothelial function is the most important component of homeostasis, it allows controlling the state of the vascular bed and providing blood supply to the organs both under physiological conditions and under the influence of pathologic factors. Scientific studies have shown the need of studying the functions of the endothelium in different categories of patients, women in particular. Endothelial dysfunction has been identified as an early marker of the development and progression of cardiovascular disease and beside that, obesity as a chronic inflammatory condition also provokes dysregulation of vascular homeostasis and leads to impaired vasodilatory function of the endothelium. It has been found that the degree of cardiovascular risk in obesity depends on the distribution of adipose tissue, and therefore on the normal functioning of the endothelium. The dysfunction of endothelium is one of the first steps in the development of cardiovascular disease. The necessity of amplification a body composition program for women with different degrees of obesity has been proved. An analysis of endothelial function before and after the program of correction of body composition was done. The results of analysis proved that dosed exercise and a transition to a healthy diet have been shown an improvement of the endothelial function and the reduction of both total adipose tissue and visceral fat.
Keywords: endothelial dysfunction, obesity, body fat composition, physical training, healthy diet.
References
Sciacqua A., Candigliota M., Ceravolo, R., Scozzafava A., Sinopoli F. et al. (2003). Weight loss in combination with physical activity improves endothelial dysfunction in human obesity. Diabetes Care, vol. 26 (6), pp. 1673–1678, DOI: 10.2337/diacare.26.6.1673.
Stegenga H., Haines A., Jones K., Wilding J., & Guideline Development Group. (2014). Identification, assessment, and management of overweight and obesity: summary of updated NICE guidance. BMJ (Clinical Research Ed.), vol. 349 (v27 2), g6608, DOI: https://doi.org/10.1136/bmj.g6608.
Tousoulis D., Kampoli A.M., Tentolouris C., Papageorgiou N., Stefanadis C. (2012). The role of nitric oxide on endothelial function. Current Vascular Pharmacology, vol. 10 (1), pp. 4–18.
Kampoli A.M., Tousoulis D., Tentolouris C., Stefanadis C. (2012). Novel agents targeting nitric oxide. Current Vascular Pharmacology, vol. 10 (1), pp. 61–76, DOI: 10.2174/157016112798829805.
Hamdy O., Ledbury S., Mullooly C., Jarema C., Porter S., Ovalle K. et al. (2003). Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes Care, vol. 26 (7), pp. 2119–2125.
Engin A. (2017). Endothelial dysfunction in obesity. Advances in Experimental Medicine and Biology, vol. 960, pp. 345–379, DOI: 10.1007/978-3-319-48382-5_15.
Pettersson-Pablo P., Cao Y., Bäckström T., Nilsson T.K. et al. (2020). Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults – The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study. BMC Cardiovascular Disorders, vol. 20 (1), p. 77, DOI: 10.1186/s12872-020-01376-6.
Polovina, M.M., Potpara T.S. (2014). Endothelial dysfunction in metabolic and vascular disorders. Postgraduate Medicine, vol. 126 (2), pp. 38–53, DOI: 10.3810/pgm.2014.03.2739.
Flammer A.J., Lüscher T.F. (2010). Three decades of endothelium research: From the detection of NO to the everyday implementation of endothelial function measurements in cardiovascular diseases. Swiss Medical Weekly, vol. 140, w13122, DOI: 10.4414/smw.2010.13122.
Ketonen J., Pilvi T., Mervaala E. (2010). Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice. Heart and Vessels, vol. 25 (3), pp. 254–262, DOI: 10.1007/s00380-009-1182-x.
Brook R.D., Bard R.L., Glazewski L., Kehrer C., Bodary P.F., Eitzman D.L. et al. (2004). Effect of short-term weight loss on the metabolic syndrome and conduit vascular endothelial function in overweight adults. The American Journal of Cardiology, vol. 93 (8), pp. 1012–1016, DOI: 10.1016/j.amjcard.2004.01.009.