Abstract
A comparative analysis of the humoral immune response in shigellosis in 90 children aged four to ten years infected with cytomegolovirus (CMV) was performed. It was found that shigellosis in young children on the background of CMV infection is characterized by torpid changes in the parameters of the main classes of immunoglobulins in the dynamics of the disease. with the exception of serum IgG. The IgG content in patients with shigellosis and infected with CMV is significantly higher both in comparison with the control group. and in children without concomitant infection. The revealed features of the response of the humoral immune system can be an auxiliary diagnostic criterion for the infection of CMV in children with shigellosis. as well as the cause of the development of an unfavorable course of the disease. which requires further investigation.
References
Malysh N., Kuznetsova A.L. (2013). Sovremennyye aspekty epidemiologii shigellezov v severo-vostochnom regione Ukrainy [Modern aspects of the epidemiology of Shigellosis in the north-eastern region of Ukraine]. Ukrainskiy meditsinskiy zhurnal - Ukrainian medical journal, № 5 (97), IX / X [in Russian].
Chemych M.D. (2005). Vplyv likuvalnykh serednykiv na perebih shyhelozu [Influence of medical agents on the course of shigellosis]. Visnyk Sumskoho derzhavnoho universytetu. Seriya Medytsyna - Visnyk of Sumy State University. Medicine series, № 7, pp. 61-69 [in Ukrainian].
Suprun E.N. (2018). Tsitokiny i autoantitela k tsitokinam [Cytokines and autoantibodies to cytokines]. Allergologiya i immunologiya v pediatrii - Allergology and immunology in pediatrics, № 2, pp. 61-65 [in Russian].
Chuklyn S.N., Pereyaslov A.A. (2015). Interleykiny [Interleukins]. Lviv: Liha-Pres, 481 p. [in Ukrainian].
Rommagnani S. (2007). The Th1/Th2 paradigm. Immunol. Today, vol. 18, pp. 253-257.
Maman Y., Nir-Paz R., Louzoun Y. (2011). Bacteria Modulate the CD8+ T Cell Epitope Repertoire of Host Cytosol-Exposed Proteins to Manipulate the Host Immune Response. PLOS Computational Biology, vol. 7 (10), DOI: 10.1371/journal.pcbi.1002220.
Orekhov K.V., Golubeva M.V., Barycheva L.Yu. (2014). Vrozhdennaya tsitomegalovirusnaya infektsiya [Congenital cytomegalovirus infection]. Detskiye infektsii - Children's infections, № 1, pp. 43-48 [in Russian].
Zalyaliyeva M.V., Prokhorova R.S. (2001). Sposoby opredeleniya subpopulyatsiy limfotsitov [Methods for determining lymphocyte subpopulations]. №1 DP 20000774 D/P MKP 6601 № 33/48 26.02.2001 [in Russian].
Chen S.F., Tu W.W., Sharp M.A., Tongson E.C., He X.S. et al. (2009). Antiviral cells in the control of primary human cytomegalovirus infection in early childhood. J Infect Dis., May 1, vol. 179 (9), pp. 1619-1627.
Shakhgildyan V.I. (2013). Gerpesvirusnyye infektsii. VICH-infektsiya i SPID: natsional'noye rukovodstvo [Herpesvirus infections. HIV infection and AIDS: national leadership]. V.V. Pokrovsky (Ed.); M.: GEOTAR-Media. 608 р. [in Russian].
Revello M.G., Gerna G. (2012). Diagnosis and management of human cytomegalovirus infection in the mother, fetus and newborn infant. Clin. Microbiol. Rev., vol. 15, pp. 680-715.
Shyrobokova V.P. (Eds.). (2011). Medychna mikrobiolohiya, virusolohiya, imunolohiya [Medical microbiology, virology, immunology]. Vinnytsia: Nova knyha, 415 p. [in Ukrainian].
Kuznetsov S.V., Hubar S.O., Zharkova T.S., Olkhovskaia O.N., Kucherenko E.O. (2014). Kriterii prognozirovaniya techeniya shigelleza u detey rannego vozrasta [Criteria for predicting the course of shigellosis in young children]. Zdravookhraneniye Tadzhikistana - Healthcare of Tajikistan, № 4 (323), pp. 75-81 [in Russian].
Vasylieva N.A., Lokai B.A. (2006). Dyferentsiyna diahnostyka khvorob iz hostrym diareynym syndromom [Differential diagnosis of diseases with acute diarrheal syndrome]. Infektsiyni khvoroby - Infectious diseases, № 1. - pp. 58-66 [in Ukrainian].