Keywords
course of the disease
clinical and laboratory parameters
immune system
How to Cite
Abstract
Today, about 85-95 % of the population is infected with EBV, therefore, the study of the nature of clinical and laboratory changes in patients with chronic EBV infection and the characteristics of the disease is an urgent problem of our time. According to the results of the study, it was found that in patients with chronic EBV infection, chronic tonsillitis, chronic fatigue syndrome and peripheral lymphadenopathy were more often observed among the clinical manifestations. In laboratory studies, it was found that patients with chronic EBV infection are characterized by a significant increase in ESR, an increase in the relative content of lymphocytes and monocytes, as well as a decrease in the absolute and relative content of neutrophils compared with the control group of patients, which indicates the presence of a shift in the leukocyte blood count, characteristic of the disease of viral etiology associated with EBV.
References
Krasnickaya АД., Borovskaya КА. (2012). Immunologicheskie aspekti chronicheskogo tonzilita, associirovannogo s virus Epsteina-Barr infekciey [Immunological aspects of chronic tonsillitis associated with Epstein-Barr virus infection]. Fundametnalnie issledovaniya - Basic research, vol. 4 (part 2), pp. 299-305 [in Russian].
Kramarev 5.О., Vigivskaya О.У (2008). Chronichni formi Epsteina-Barr virusniyi infekcii u ditey: suchasni pidhodi do diagnostiki ta likuvannya [Chronic forms of Epstein-Barr viral infections in children: modern way to diagnostics and treatment]. Sovremennaya pediatriya - Modern pediatrics, vol. 2 (19), pp. 103-108 [in Ukrainian].
Popov M., Lyadova T., Volobuyeva O. et al. (2017). Cytokine production peculiarities in different forms of Epstain-Barr virus infection. Georgian medical news, № 2 (263), pp. 55-59.
Duda О.К., Kolesnik Р.О., Оkruzhnov M.V, Boyko У.О. (2015). Clinichni formi chronichnoi Epsteina-Barr virusnoi infekcii: pitannya suchasnoi diagnistiki ta likuvannya [Clinical forms of chronic
Epstein-Barr virus infection: nutrition of the current diagnostics and treatment]. Aktualnaya infectologiya - Actual infectious diseases, № 1 (6), pp. 42-46 [in Ukrainian].
Cohen Jeffrey I., Jaffe Elaine S., Dale Janet K. et al. (2011). Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States. Blood, vol. 117 (22), pp. 5835-5849.
Sorokina O.G. (2018). Doslidzhennya stanu klitinnogo imunitetu u chvorih na chronichnu VEB- infekciyu [Prior to becoming a clerical immunity in ailing on chronic WEB-infection]. Imunologiya ta alergologiya: nauka ta praktika - Immunology and allergology: science and practice, № 3, pp 65-70 [in Ukrainian].
Sorokina O.G. (2018). Charakteristica pokaznikiv gumoralnogo imunitetu u chvorih na chronichnu VEB-infekciyu [Characteristics of indicators of humoral immunity in ailments on chronic WEB-infection]. Eksperimentalna i klinichna medicina - Experimental and clinical medicine, № 2-3 (79-80), pp. 57-60 [in Ukrainian].
Kolesnik Ya., Zharkova T., Rzhevskaya 0. et al. (2018). Clinical and immunological criteria for adverse course of infectious mononucleosis in children. Georgian medical news, № 5 (278), pp. 132-138.