Abstract
The changes in hormonal homeostasis, hematopoiesis and pathomorphosis of the tumor were studied in 152 patients with breast cancer (T2N0M0 and T3N1M0). Patients of the main group received from 5 to 10 sessions of intravenous laser irradiation of blood (VLOK). After a complete course of VLOK (10 sessions), the devitalization of the tumor parenchyma was observed (decrease in the volume fraction of viable cells by 30%); restoration of hematopoiesis and hormonal homeostasis, indicating a local and systemic therapeutic effect of ILBL.References
Bril H.Ye. (2007). Nekotoryie metodolohicheskiie aspekty izucheniia biolohicheskikh effektov nizkointensivnoho lazernoho izlucheniia [Some methodological aspects of studying the biological effects of low-intensity laser radiation.]. Fotobiolohiia i fotomeditsina – Photobiology and photomedicine, № 1–2, pp. 5–13 [in Russian].
Silveira P.C., Streck E.L., Pinho R.A. (2007). Evaluation of mitochondrial respiratory chain activity in wound healing by low-level laser therapy. J. Photochem. Photobiol. B: Biology, vol. 86, pp. 279–282.
Kuzmina I.Yu., Krauze T.M. (2006). Sovremennyie aspekty lazeroterapii [Modern aspects of laser therapy]. Mezhdunarodnyi meditsinskii zhurnal – International Medical Journal, № 2 (12), pp. 106–110 [in Russian].
Bril H.Ye., Bril A.H. (1997). Huanilattsiklaza i NO-sintetaza – vozmozhnyie pervichnyie aktseptory enerhii nizkointensivnoho lazernoho izlucheniia [Guanylate cyclase and NO-synthetase – possible primary energy acceptors of low-intensity laser radiation]. Lazernaia meditsina – Laser Medicine, № 2 (1), pp. 39–42 [in Russian].
Deviatkov N.D., Zubkova S.M., Laprun I.B. (1987). Fiziko-khimicheskiie mekhanizmy biolohicheskoho deistviia lazernoho izlucheniia [Physico-chemical mechanisms of the biological action of laser radiation]. Uspekhi sovremennoi biolohii – Successes of Modern Biology, № 1 (103), pp. 31–43 [in Russian].
Voltovskaia A.V., Ulashchik V.S., Filipovich V.M. (2003). Antioksidantnoie deistviie i terapevticheskaia effektivnost lazernoho oblucheniia krovi u bolnykh s ishemicheskoi bolezniu serdtsa [Antioxidant effect and therapeutic efficacy of laser irradiation of blood in patients with coronary heart disease]. Voprosy kurortologii – Questions of Balneology, № 3, pp. 22–25 [in Russian].
Simunovic Z., Ivancov A.D., Depolo A. (2000). Wound healing of animal and human body sport and traffic accident injures using low-level laser therapy treatment. J. Clin. Laser. Med. Surg., № 2 (18), pp. 67–73.
Stranadko Ye.F. (2011). Fotodinamicheskaia terapiia hnoino-vospalitelnykh zabolevanii miahkikh tkanei [Photodynamic therapy of purulent-inflammatory diseases of soft tissues]. Fotobiolohiia i fotomeditsina – Photobiology and Photomedicine, № 2, pp. 14–19 [in Russian].
Skliar N.I., Simonova-Pushkar L.I., Sarkis-Ivanova V.V., Hertman V.Z. (2016). Mikrobiolohichne obgruntuvannia efektyvnosti fotodynamichnoi terapii na eksperymentalnii modeli infikovanoi promenevoi vyrazky shkiry [Microbiological substantiation of the effectiveness of photodynamic therapy on the experimental model of infected skin ulcer]. Aktualni problemy suchasnoi medytsyny – Actual Problems of Modern Medicine, vol. 4 (56), part 3, pp. 61–65 [in Ukrainian].
Cherdyntseva N.V., Kuznetsova A.A., Mukhammedov M.R. (2002). Vliianiie izucheniia lazera na parakh medi na pokazateli sistemy immuniteta u bolnykh s opukholiami holovy i shei, poluchavshikh distantsionnuiu elektronnuiu terapiiu [The effect of studying copper vapor laser on the immune system parameters in patients with head and neck tumors who received remote electronic therapy]. Rossiiskii onkolohicheskii zhurnal – Russian Oncology Journal, № 1, pp. 21–26 [in Russian].
Ustiianovych O.S., Klihunenko O.M., Stanin D.M. et al. (2007). Dosvid vykorystannia ekstrokorporalnykh metodiv detoksykatsii v ambulatornykh umovakh [Experience of using extracorporal methods of detoxification in outpatient settings]. Proceedings from Bil, zneboliuvannia ta intensyvna terapiia: I Ukrainskoi naukovo-praktychnoi konferentsii z zastosuvannia eferentnykh metodiv terapii – Pain, Anesthesia and Intensive Care: I Ukrainian scientific and practical conference on the use of efferent therapies. Kiev, pp. 52–53 [in Ukrainian].
Skliarenko V.H., Shevchenko Yu.H. (2004). Ekstrakorporalnaia hemokorrektsiia i kvantovaia terapiia. Chast 1 [Extracorporeal hemocorrection and quantum therapy. Part 1]. Kiev, 160 p. [in Russian].
Ovsiannikov V.A. (2004). Bezopasnost lazernoi terapii s tochki zreniia enerheticheskoi teorii vozniknoveniia rakovykh zabolevanii [The safety of laser therapy in terms of the energy theory of cancer]. Lazernaia meditsina – Laser medicine, vol. 8 (1–2), pp. 76–85 [in Russian].
Kovalenko I.M., Bershtein L.M. (2017). Sravnitelnyie hormon-assotsiirovannyie i kliniko-morfolohicheskiie osobennosti raka molochnoi zhelezy i endometriia u bolnykh, stradaiushchikh i ne stradaiushchikh diabetom [Comparative hormone-associated and clinico-morphological features of breast and endometrial cancer in patients with and without diabetes]. Voprosy onkolohii – Oncology Issues, № 5, pp. 752–757 [in Russian].
Halakhin K.A., Kurik Ye.H. (2000). Lechebnyi patomorfoz zlokachestvennykh opukholei pishchevaritelnoho trakta [Therapeutic pathomorphosis of malignant tumors of the digestive tract]. Kiev: Kniha-plius, 160 p. [in Russian].
Menshikov V.H. (Eds.). (1987). Laboratornyie metody issledovaniia v klinike: Spravochnik [Laboratory research methods in the clinic: a Handbook]. Мoscow: Meditsina, pp. 106–125 [in Russian].