Keywords
obesity
interleukin-15
How to Cite
Abstract
In this article the results of IL-15 research of patients with obesity and HBP (high blood pressure). The research shows the dependence between IL-15 reduction in hemolinph and degree of obesity. This article discuss if there is possibility of mass regulation with the help of IL-15. It's recommended, to detect the plazma level of IL-15 for patients with HBP, it allows to improve early diagnostic of risk of development of obesity.References
Goran M.I. Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents / M.I. Goran, G.D. Ball, M.L. Cruz // J. Clin. Endocrinol. Metab. – 2003. – Vol. 88. – P. 1417–1427.
Prevalence of obesity, diabets, and obesity-related health risk factors / A.H. Mokdad, E.S. Ford, B.A. Bownan et al. // JAMA. – 2003. – Vol. 289. – P. 76–79.
Obesity associated hypertension / K. Rahmouni, M.L. Correia, W.G. Haynes, A.L. Mark // Hypertension. – 2005. – Vol. 45. – P. 9–17.
Ashton W.D. Body mass index and metabolic risk factors for coronary heart disease in women / W.D. Ashton, K. Nanchahal, D.A. Wood // Eur. Heart J. – 2001. – Vol. 22. – P. 46–55.
Risk Stratification of obesity as a coronary risk factor / W.B. Kannel, P.W. Wilson, B.H. Nam, R.B. D'Agostino // Am. J. Cardiol. – 2002. – Vol. 90. – P. 697–701.
Elevated blood pressure in transgenic lipoatrophic mice and altered vascular function / K. Takemori, Y-J. Gao, L. Ding et al. // Hypertension. – 2007. – Vol. 49 (2). – P. 365–372.
Influence of obesity on cardiovascular risk. Twenty-three-year follow-up of 22,025 men from an urban Swedish population / S. Jonsson, B. Hedblad, G. Engstrom et al. // Int. J. Obes. Relat. Metab. Disord. – 2002. – Vol. 8. – P. 1046 – 1053.
Cardiovascular Mortality in Overweight Subjects. The Key Role of Associated Risk Factors / F. Thomas, K. Bean, B. Pannier et. al. // Hypertension. – 2005. – Vol. 46. – P. 654–663.
Abel E.D. Cardiac remodeling in obesity / E.D. Abel, S.E. Litwin, G. Sweeney // Physiol. Rev. – 2008. – Vol. 88 (2). – P. 389–419.
All-Cause Mortality Associated With Specific Combinations of the Metabolic Syndrome According to Recent Definitions / L. Guize, F. Thomas, B. Pannier et al. // Diabetes Care. – 2007. – Vol. 30 (9). – P. 2381–2387.
Narkiewiez K. Obesity and hypertension – the issue is more complex than we thought / K. Narkiewiez // Nephrol. Dial. Transplant. – 2006. – Vol. 21(2). – P. 264–267.
Patidar M. Interleukin 15: A key cytokine for immunotherapy / M. Patidar, N. Yadav, S.K. Dalai // Cytokine Growth Factor Rev. – 2016; Jun. – Vol. 7. – P. 1359–1361.
Fehniger T.A., Caligiuri M.A. Interleukin 15: biology and relevance to human disease / T.A. Fehniger, M.A. Caligiuri // Blood. – 2001. – Vol. 97 (1). – P. 14–32.
Pierce J.R. IL-15 concentrations in skeletal muscle and subcutaneous adipose tissue in lean and obese humans: local effects of IL-15 on adipose tissue lipolysis / J.R. Pierce, J.M. Maples, R.C. Hickner // Am. J. Physiol. Endocrinol. Metab. – 2015. – Vol. 308. – P. 1131–1139.
Human NK cells maintain licensing status and are subject to killer immunoglobulin-like receptor (KIR) and KIR-ligand inhibition following ex vivo expansion / W. Wang, A.K. Erbe, K.A. Alderson et. al.// Cancer Immunol Immunother. – 2016; Sep. – Vol. 65 (9). – P. 1047–1059.
Pistilli E.E. From anabolic to oxidative: reconsidering the roles of IL-15 and IL-15Rα in skeletal muscle / E.E. Pistilli, L.S.Quinn // Exerc. Sport Sci Rev. – 2013; Apr. – Vol. 41 (2). – P. 100–106.
Nielsen A.R. The biological roles of exercise-induced cytokines: IL-6, IL-8, and IL-15 / A.R. Nielsen, B.K. Pedersen // Appl. Physiol. Nutr. Metab. – 2007; Oct. – Vol. 32 (5). – P. 833–839.
Association between interleukin-15 and obesity: Interleukin-15 as a potential regulator of fat mass / A.R. Nielsen, P. Hojman, C. Erikstrup et al. // J. Clin. Endocrinol. Metab. – 2008; Nov. – Vol. 93 (11). – P. 4486–4493.