Keywords
liposomal vaccine
phosphatidylcholine
lipid peroxide oxidation
How to Cite
Abstract
In base SO "Mechnikov Institute Microbiology and Immunology in the scientific theme "Developing new approaches to creating viral vaccines and study specific activity depending of type and degree component`s modification" was created several experimental influenza liposomal vaccines with subsequent component`s modification for selecting the most optimal pattern of safety and immunogenicity. It was determined the activity of the processes lipids and proteins peroxidation in serum after the administration officinal and experimental vaccines (content carbonyl groups of proteins, lipid hydroperoxides, glutathione peroxidase activity). Study objects were trivalent seasonal influenza vaccine, "Vaxigrip" (Sanofi Pasteur, S.A., France), "Inflexal V" (Biotech Ltd. Berne, Switzerland) and experimental vaccine samples. Highest immunogenicity vaccines had undergone improvements and modifications using adjuvant systems and acylation influenza proteins. "Lipos 1.1" - a sample with a positive charge of the liposomes surface and split antigenic composition the eastern to the split vaccine Vaxigrip with the addition of chlorophyll and etonium, as adjuvants and Lipos 1.2 - adjuvant, with an additional modification of the antigenic composition of the partial acylation.References
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