Changes of sub-population composition of lymphocytes after radical treatment of patients with uterine cancer with obesity
Vol 79 No 2–3 (2018), Theoretical and Experimental Medicine
Vol 79 No 2–3 (2018)

Changes of sub-population composition of lymphocytes after radical treatment of patients with uterine cancer with obesity

Theoretical and Experimental Medicine
Published July 9, 2020
P.P. Sorochan
State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
І.А. Gromakova
State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
N.E. Prokhach
State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
E.V. Kuzmenko
State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
І.S. Gromakova
State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
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Keywords

subpopulation composition of lymphocytes
cancer of the uterus
obesity

How to Cite

Sorochan, P., GromakovaІ., Prokhach, N., Kuzmenko, E., & GromakovaІ. (2020). Changes of sub-population composition of lymphocytes after radical treatment of patients with uterine cancer with obesity. Experimental and Clinical Medicine, 79(2–3), 61-65. Retrieved from https://ecm.knmu.edu.ua/article/view/409
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Abstract

Changes of sub-population composition of lymphocytes after radical treatment of patients with uterine cancer with obesity Changes in the subpopulation composition of lymphocytes in obese cancer patients after radiation treatment are analyzed. Even before treatment, an increased ratio of СD4+/CD8+ was found in all obese patients compared to normal-weight patients, and patients with III degree of obesity had an increased relative number of NKT cells and a reduced relative number of CD19+-lymphocytes. After radiation in obese patients, an increase in the relative amount of CD3+-lymphocytes and a further increase in the ratio of СD4+/CD8+ is noted. In patients with obesity, after treatment, there was also a greater deficit of absolute quantity of NK cells, which may be involved in increasing the risk of infectious complications of cancer treatment in these patients.
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References

Zhang Y., Liu H., Yang S., Zhang J., Qian L., Chen X. (2014). Overweight, obesity and endometrial cancer risk: results from a systematic review and meta-analysis. Int. J. Biol. Markers, vol. 29, № 1, pp. e21– e29.

Iyengar N.M., Gucalp A., Dannenberg A.J., Hudis C.A. (2016). Obesity and cancer mechanisms: tumor microenvironment and inflammation. J. Clin. Oncol, vol. 34, № 35, pp. 4270–4276.

Himbert C., Delphan M., Scherer D., Bowers L.W., Hursting S., Ulrich C.M. (2017). Signals from the adipose microenvironment and the obesity-cancer link-A systematic review. Cancer Prev Res (Phila), Sep; vol. 10 (9), pp. 494–506.

Dandapani S.V., Zhang Y., Jennelle R., Lin Y.G. (2015). Radiation-sociated toxicities in obese women with endometrial cancer: more than just BMI? Scientific World J, vol. 2015, Article ID 483208.

Satoh M., Iwabuchi K. (2018). Role of natural killer T cells in the development of obesity and insulin resistance: insights from recent progress. Front. Immunol, vol. 9, Article ID 1314.

Crowe N.Y., Uldrich A.P., Kyparissoudis K., Hammond K.J., Hayakawa Y., Sidobre S., Keating R. et al. (2003). Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. J. Immunol, vol. 171, № 8, pp 4020–4027.

Chang D.H., Osman K., Connolly J., Kukreja A., Krasovsky J., Pack M. (2005). Sustained expansion of NKT cells and antigen-specific T cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients. J. Exp. Med. vol. 201, № 9, pp. 1503–1517.

Van der Weerd K., Dik W.A., Schrijver B., Schweitzer D.H., Langerak A.W., Drexhage H.A. et al. (2012). Morbidly obese human subjects have increased peripheral blood CD4+ T cells with skewing toward a Treg- and Th2-dominated phenotype. Diabetes, vol. 61, № 2, pp. 401–408.