Dysfunction of erythrocytes in the conditions of nitroxidative stress in the development of vascular pathology
Vol 79 No 2–3 (2018), Theoretical and Experimental Medicine
Vol 79 No 2–3 (2018)

Dysfunction of erythrocytes in the conditions of nitroxidative stress in the development of vascular pathology

Theoretical and Experimental Medicine
Published July 9, 2020
V.V. Ramazanov
Institute of Cryobiology and Cryomedicine Problems of the National Academy of Sciences of Ukraine, Kharkov
E.L. Volovelskaya
Institute of Cryobiology and Cryomedicine Problems of the National Academy of Sciences of Ukraine, Kharkov
E.E. Nipot
Institute of Cryobiology and Cryomedicine Problems of the National Academy of Sciences of Ukraine, Kharkov
S.S. Ershov
Institute of Cryobiology and Cryomedicine Problems of the National Academy of Sciences of Ukraine, Kharkov
N.A. Ershova
Institute of Cryobiology and Cryomedicine Problems of the National Academy of Sciences of Ukraine, Kharkov
S.V. Rudenko
Institute of Cryobiology and Cryomedicine Problems of the National Academy of Sciences of Ukraine, Kharkov
V.V. Ryazantsev
Institute of Cryobiology and Cryomedicine Problems of the National Academy of Sciences of Ukraine, Kharkov
V.A. Bondarenko
Institute of Cryobiology and Cryomedicine Problems of the National Academy of Sciences of Ukraine, Kharkov
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Keywords

erythrocytes
nitroxidative stress
vascular pathology

How to Cite

Ramazanov, V., Volovelskaya, E., Nipot, E., Ershov, S., Ershova, N., Rudenko, S., Ryazantsev, V., & Bondarenko, V. (2020). Dysfunction of erythrocytes in the conditions of nitroxidative stress in the development of vascular pathology. Experimental and Clinical Medicine, 79(2–3), 50-56. Retrieved from https://ecm.knmu.edu.ua/article/view/402
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Abstract

The prospects of developing several pharmacological strategies related to detoxification of peroxynitrite and inhibition of the nitration of protein tyrosines by this nitroxidant are being considered. An increase in the level of nitrotyrosine is a consequence of the pathogenic mechanism of superoxide-induced endothelial dysfunction observed in various diseases. A significant part of peroxynitrite is neutralized by erythrocytes; however, with nitroxidative stress, their dysfunction develops, which can contribute to micro- and macrovascular diseases. In this aspect internal erythrocyte dysfunction can be the object of attention for investigating the possibility of developing a pharmacological strategy for stimulating the antioxidant potential of red blood cells.
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