Changes of C-reactive protein concentration in rats with periodontitis on the background of hyper- and hypothyroidism
PDF (Українська)

Keywords

periodontitis
thyroid hormones
inflammation

How to Cite

Shcherba, V., Krynytska, I., Miz, A., & М.М. (2020). Changes of C-reactive protein concentration in rats with periodontitis on the background of hyper- and hypothyroidism. Experimental and Clinical Medicine, 77(4), 22-28. Retrieved from https://ecm.knmu.edu.ua/article/view/401

Abstract

The article presents data on the influence of the thyroid gland pathology on the course of periodontal inflammatory processes. Experimental periodontitis is accompanied by a marked increase in the concentration of the C-reactive protein, both in the homogenate of the periodontal tissues and in the blood serum, which indicates the development of not only local inflammatory reactions but also systemic ones. Imbalance of thyroid hormones affects the course of inflammation in case of experimental periodontitis, especially expressed in hyperthyroidism.
PDF (Українська)

References

Shylo M.M. (2013). Vikovi osoblyvosti formuvannya zapal'nykh khvorob parodonta u ditey v zalezhnosti vid klinichnykh form tuberkul'ozu [Age features of the formation of periodontal inflammatory diseases in children depending on clinical forms of tuberculosis]. Ukrayins'kyy pul'monolohichnyy zhurnal – Ukrainian pulmonologist magazine. 4: 41–43 [in Ukrainian].

Nikolaeva A.V., Makarenko O.A. (2016). Izuchenie stepeni destruktivnih izmeneniy v tkanyah parodonta pri modelirovanii parodonti ta u belyih kryis-samok razlichnyih vozrastnyih periodov [The study of the degree of destructive changes in periodontal tissue in the modeling of periodontitis in white rats – females of different age periods]. Klіnіchna ta eksperimentalna patologіya – Clinical and Experimental Pathology. XV, 4 (58): 74–78 [in Ukrainian].

Savas Е., Ziya Sahin А., Aksoy S.N., Tascan А., Sayıner Z.A., Ozkaya М. (2016). Serum levels of inflammatory markers in patients with thyroid dysfunction and their association with autoimmunity status. Int J Clin Exp Med. 9 (2): 4485–4490.

Gasparyan A.Y., Ayvazyan L., Mikhailidi, D.P., Kitas K.D. (2011). Mean platelet volume: a link be¬tween thrombosis and inflammation. Curr Pharm. 17: 47–58.

Bansal T., Pandey A.D.D., Asthana A.K. (2014). C-Reactive Protein (CRP) and its Association with Periodontal Disease: A Brief Review. J. Clinical and Diagnostic Research. 8 (7): ZE21-ZE24.

Sabirova A.I. (2016). Tsitokinovyiy status u bolnyih generalizovannyim parodontitom i metabolicheskim sindromom [Cytokine status in patients with generalized periodontitis and metabolic syndrome]. Vestnik KRSU – Herald of the KRSU. 16, 7: 102–105 [in Ukrainian].

Moyseeva E.H. (2008). Metabolycheskyi homeostaz y imunnaia reaktyvnost orhanyzma v dynamyke vospalenyia v tkaniakh parodonta [Metabolic homeostasis and immune reactivity of the organism in the dynamics of inflammation in periodontal tissues]. Extended abstract of Doctor’s thesis. Sumy: SumSU [in Russian].

Ratushnenko V.O. (2010). Funktsionalna rol tiol-dysulfidnoi systemy pry eksperymentalnomu hipo- i hipertyreozi [Functional role of thiol-disulphide system in experimental hypo- and hyperthyroidism]. Odeskyi medychnyi zhurnal – Odessa Medical Journal. 2 (118): 17–20 [in Ukrainian].

European convention for the protection of vertebrate animals used for experimental and other scientific purposes. (1986). Council of Europe. Strasbourg. 123: 52.

Avdieiev O.V. (2013). Stupin aktyvnosti fosfataz pry eksperymentalnomu parodontyti ta za yoho korektsii [Stupin activity of phosphatases during experimental parodontitis and after correction]. Klinichna stomatolohiia – Clinical stomatology. 3–4: 13–17 [in Ukrainian].

Lu Q., & Jin L. (2010). Human gingiva is another site of C-reactive protein formation. J. Clin. Periodontol. 37 (9): 789–796.

Ide M., McPartlin D., Coward P.Y., Crook M., Lumb, P., & Wilson R.F. (2003). Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. J. Clin. Periodontol. 30: 334–340.

Gomes-Filho I.S., Coelho J.M.F., Cruz S.S., Passos J.S., Freitas C.O.T., Farias N.S.A. et al. (2011). Chronic periodontitis and C-reactive protein levels. J. Periodontol. 82: 969–978.

Noack B., Genco R.J., Trevisan M., Grossi S., Zambon J.J., Nardin E.D. (2001). Periodontal infections contribute to elevated systemic C-reactive protein level. J. Periodontol. 72: 1221–1227.

Czarnywojtek A., Owecki M., Zgorzalewicz-Stachowiak М., et al. (2014). The Role of Serum C-Reactive Protein Measured by High-Sensitive Method in Thyroid Disease. Arch. Immunol. Ther. Exp. (Warsz). 62 (6): 501–509.

Kvetny J., Heldgaard P.E., Bladbjerg E.M., Gram J. (2004). Subclinical hypothyroidism is associated with a low grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years. Clin. Endocrinol (Oxf). 61: 232–238.

Yao H.H., Li Y.H., Zhang X.W., Li Z.G. (2011). Clinical analy¬sis and immunological characteristics of pa¬tients with dermatomyositis and thyroid dys¬function. Beijing Da Xue Xue Bao, 43, 209–212.

Tuzcu, А., Bahceci, М., Gokalp, D., et al. (2005). Subclinical hypothyroidism may be associated with elevated high-sensitive C-reactive protein (low grade inflammation) and fasting hyperinsulinemia. Endocr J. 52: 89–94.

Hueston W.J., King D.E., Geesey М.Е. (2005). Serum biomarkers for cardiovascular inflammation in subclinical hypothyroidism. Clin. Endocrinol. (Oxf). 63: 582–587.

Pligovka V.N., Fadeenko G.D. (2014). Vliyanie bessimptomnoy giperurikemii na metabolicheskie pokazateli i tolschinu kompleksa intima u bolnyih gipertonicheskoy boleznyu s ozhireniem i gipofunktsiey schitovidnoy zhelezyi [Influence of asymptomatic hyperuricemia on metabolic parameters and thickness of the intima complex in patients with hypertensive disease with obesity and hypothyroidism of the thyroid gland]. Visnyk problem biolohiyi i medytsyny – Bulletin of Biology and Medicine. 4 (2): 177–181[in Ukrainian].