Results of biodegradable polymeric materials application in the treatment of skin ІІІb degree burns in the experiment
PDF (Українська)

Keywords

polymer film
zinc nan-oxide
thermal burn
wounds
experiment

How to Cite

Popadyuk, O. (2020). Results of biodegradable polymeric materials application in the treatment of skin ІІІb degree burns in the experiment. Experimental and Clinical Medicine, 79(2–3), 41-49. Retrieved from https://ecm.knmu.edu.ua/article/view/400

Abstract

The wound healing properties of biodegradable polymer materials developed by us in the form of the films «biodep» and «biodep nano» have been studied experimentally on the animals. The films were applied to the wound surface of the experimentally induced skin ІІІb degree burn after surgical removing necrotic tissues; the wound condition and its surrounding tissues were observed, and wound healing planimetric and pathomorphological parameters were studied. The obtained results showed that the developed polymer films improve the burn wound healing, reduce the inflammation of the wound tissues, and the film saturated with zinc oxide effectively destroys the microbial flora in the burn wounds and prevents the development of purulent process. It is established that biodegradable polymeric film «biodep nano» is a highly effective means of healing burn wounds, and zinc nano-oxide as one of the film components has excellent antimicrobial properties, and does not cause negative influence on the wound and its surrounding tissues.
PDF (Українська)

References

WHO. A WHO plan for burn prevention and care (2008). World Health Organization.

Brusselaers N., Monstrey S., Vogelaers D., Hoste E., Blot S. (2013). Severe burn injury in Europe: a systematic review of the incidence, etiology, morbidity, and mortality. Int. J. Pharm. Life Sci, vol. 4 (12), pp. 3151–3158.

Ahn C.S., Maitz P.K. (2012). The true cost of burn. Burns, vol. 38 (7), pp. 967–974.

Herdon D.N. (2012). Total burn care. Oxford: Saunders. 4th еd., p. 808.

Pollock R.E., Brunicardi F.C., Andersen D.K., Billiar T.R., David D., Hunter J.G., Matthews J.J. (2009). The cellular, biochemical, and mechanical phases of wound healing. Schwartz's Principles of Surgery, Ninth Edition. McGraw-Hill Professional.

Rudenko V.V., Shmatenko O.P., Prytula R.L. (2013). Farmakoekonomichnyi analiz likarskykh preparativ dlia mistsevoho zastosuvannia u II fazi ranovoho protsesu [Pharmacoeconomic analysis of medicinal products for local use in the second phase of the wound process]. Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky – Actual questions of pharmaceutical and medical science and practice, vol. 12 (2), pp. 121–123 [in Ukrainian].

Yakovlieva L.V., Tkachova O.V., Butko Ya.O. (2013). Eksperymentalne vyvchennia novykh preparativ dlia mistsevoho likuvannya ran: Metod. Rekomendatsiyi [Experimental study of new drugs for local wound healing: Method. recommendations]. K. : DETS MOZ Ukrayiny. 52 p. [in Ukrainian].

Butzelaar L., Ulrich M.M., Mink van der Molen A.B., Niessen F.B., Beelen R.H. (2016). Currently known risk factors for hypertrophic skin scarring: a review. Clin. Infect. Dis., vol. 69 (2), pp. 163–169. DOI: 10.1016/j.bjps.2015.11.015.

Bayram Y., Deveci M., Imirzalioglu N., Soysal Y., Sengezer M. (2005). The cell based dressing with living allogenic keratinocytes in the treatment of foot ulcers: a case study. British Journal of Plastic Surgery, vol. 58 (7), pp. 988–996.

Kryzyna P.S. (2001). Osoblyvosti perebihu zapalnoho protsesu v infikovanykh ranakh pry zastosuvanni dlia pokryttia iikh poverkhni hidrattseliuloznoiu plivkoiu ta AVVM [Peculiarities of the inflammation process in infected wounds when applied to cover their surface with a hydrated cellulose film and AVVM]. "Dnepr" MP. Bukovinian medical herald. vol. 5 (1), pp. 173–176 [in Ukrainian].

Paramonov B.A., Porembskii Ya.O., Yablonskii V.G. (2000). Ozhohi: Rukovodstvo dlia vrachei [Burns: a guide for doctors]. SPb.: SpetsLit, 480 p. [in Russian].

Grihorian S.Kh., Grihoryan A.K., Nanian A.S., Grihoryan E.S. (2001). Sravnitelnoie izucheniie effektivnosti razlichnykh bioaktivnykh materialov pri lechenii hnoynykh ran [Comparative study of the effectiveness of various bioactive materials in the treatment of purulent wounds]. Materialy Mezhdunarodnoi konferentsii – Materials of the International Conference, ed. V.D. Fedorov, A.A. Adamyan. Moscow; pp. 101–102 [in Russian].

Dobysh S.V., Vasiliev A.V., Shurupova O.V. (2001). Sovremennyie pereviazochnyie sredstva dlia lecheniia ran vo vtoroi faze ranevoho protsessa [Modern dressings for the treatment of wounds in the second phase of the wound process]. Materialy Mezhdunarodnoy Konferentsii – Materials of the International Conference. Moscow, p. 115 [in Russian].

Okan D., Woo K., Ayello E., Sibbald G. (2007). The Role of Moisture Balance in Wound Healing. Adv. Skin Wound Care, vol. 20 (1). pp. 39–53.

Ovington L. (2002). Hanging Wet-to-Dry Dressings out to Dry. Adv. Skin Wound Care, vol. 15 (2), pp. 79–86.

Ryssel H., Germann G., Kloeters O., Gazyakan E., Radu C.A. (2010). Dermal substitution with Matriderm® in burns on the dorsum of the hand. Burns, vol. 36 (8), pp. 1248–1253. DOI: https://doi.org/10.1016/j.burns.2010.05.003

Barreto R.S., Quintans J.S., Barreto A.S., Albuquerque-Júnior R.L., Galvão J.G., Gonsalves J.K. et al. (2016). Improvement of wound tissue repair by chitosan films containing-borneol, a bicyclic monoterpene alcohol, in rats. International Wound Journal, vol. 13, pp. 799–808.

Munteanu C., Munteanu D., Simionca I., Hoteteu M. (2010). In vitro experimental evaluation of wound and burns healing capacity after exposure to salty microclimate from Dej and Cacica. Balneo-Research Journal, vol. 1 (1), pp. 30–34.

Fernandes A.C., França J.P., Gaiba S., Aloise A.C., Oliveira A.F., Moraes A.A. et al. (2014). Development of experimental in vitro burn model. Acta Cirúrgica Brasileira, vol. 29 (2), pp. 15–20. DOI: http://dx.doi.org/10.1590/S0102-86502014001400004

Korniienko V.V. (2013). Planimetriia poverkhni opikovoii rany pry vykorystanni khitozanovykh membran [Planimetry of the burn wound surface using chitosan membranes]. Zhurnal klinichnykh ta eksperymentalnykh medychnykh doslidzhen – Journal of Clinical and Experimental Medical Research, vol. 1 (4), pp. 390–397 [in Ukrainian].

Melnyk D.O., Melnyk M.V., Popadiuk O.Ya., Nechytaylo M.Yu., Henyk S.M. Biodehraduyucha polimerna osnova «biodep» [Biodedaging polymer base «biodept»]: pat. 112145 UA; stated. May 20, 2016; has published 10.10.2016, Byul. №. 19

Popadiuk O.Ya., Henyek S.M., Nechytaylo M.Yu., Melnyk M.V., Melnyk D.O. Biodehraduyucha polimerna plivka «biodep-nano» [Biodedaging polymeric film «biodept-nano»]: pat. 110594 UA; stated. May 20, 2016; has published 10.10.2016, Byul. № 19.

Popadyuk O.Ya. (2017). Otsenka dehradiruyushchikh i mekhanicheskikh svoistv nanosoderzhashchikh ranozazhivlyaiushchikh polimernykh materialov [Evaluation of the degrading and mechanical properties of nano-containing wound healing polymeric materials]. Novosti khirurhii – Surgery news, vol. 25 (5), pp. 454–458 [in Russian].

Popadyuk O.Ya. (2013). Patomorfolohichni osoblyvosti vidnovlennia poshkodzhenykh miakykh tkanyn iz zastosuvanniam biorozchynnoii polimernoii plivky v eksperymenti [Pathomorphological features of restoration of damaged soft tissue using biodegradable polymer film in the experiment]. Ukrayinskyi Zhurnal Khirurhii – Ukrainian Journal of Surgery, vol. 4 (23), pp. 67–72 [in Ukrainian].

UTHSCSA ImageTool 2.0. The University of Texas Health ScienceCenter in San Antonio, 1995–1996. Retrieved from: http://ddsdx.uthscsa.edu

Singer A.J., Berruti L., Thode Jr.H.C., Mcclain S.A. (2000). Standardized burn model using a multiparametric histologic analysis of burn depth. Academic Emergency Medicine, vol. 7 (1), pp. 1–6.

Campelo A.P.B.S., Campelo M.W.S., Castro Britto G.A., Ayala A.P., Guimarães S.B., de Vasconcelos P.R.L. (2011). A optimized animal model for partial and total skin thickness burns studies. Acta Cirurgica Brasileira, vol. 26 (1), pp. 38–42.

Chadaiev A.P., Klimiashvili A.D. (2003). Sovremennyie metodiki mestnoho medikamentoznoho lecheniia infitsirovannykh ran [Modern methods of local drug treatment of infected wounds]. Khirurhiia – Surgery, vol. 9, pp. 54–56 [in Russian].

Venter N.G., Monte-Alto-Costa A., Marques R.G. (2015). A new model for the standardization of experimental burn wounds. Burns, vol. 41 (3), pp. 542–547.