Comparative study of biochemical parameters of mice with Рseudomonas burn infection treated by new application sorbents
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Keywords

burn infection
application sorbent
lipid peroxidation
C-reactive protein
acute phase proteins

How to Cite

Cherniakova, G., Minukhin, V., & Горбач, Т. (2020). Comparative study of biochemical parameters of mice with Рseudomonas burn infection treated by new application sorbents. Experimental and Clinical Medicine, 77(4), 15-21. Retrieved from https://ecm.knmu.edu.ua/article/view/398

Abstract

Thermal trauma is associated with biochemical changes in the macroorganism. It was compared the levels of lipid peroxidation, total antioxidant activity and acute phase protein in animals with Pseudomonas-infection of burn wounds during treatment with experimental application sorbents and silver sulfadiazine. It was shown that the level of levels of lipid peroxidation in animals treated with an application sorbent with levofloxacin was lowering for the second week and the level of total antioxidant activity was increased by the third week, which indicated as positive trend. Normalization of acute phase proteins levels was on the 14th day. It can be assumed that the use of the application sorbent with levofloxacin accelerates the process of normalizing the biochemical indices of the macroorganism and, thus, affects the earlier onset of healing of the infected burn wound in the experiment.
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