Association of vascular calcification and osteopontin concentration in blood plasma in patients on renal replacement therapy by peritoneal dialysis
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Keywords

chronic kidney disease
peritoneal dialysis
bone mineral metabolism
osteopontin
vascular calcification

How to Cite

Valkovskaya, T. (2020). Association of vascular calcification and osteopontin concentration in blood plasma in patients on renal replacement therapy by peritoneal dialysis. Experimental and Clinical Medicine, 82(1), 81-86. https://doi.org/10.35339/ekm.2019.01.12

Abstract

The study of the frequency of calcification of the abdominal aorta and the role of the plasma fraction of osteopontin in its development and the relationship between the degree of violation of phosphorus-calcium metabolism in patients with chronic kidney disease stage 5 on peritoneal dialysis. It was found that calcification of the abdominal aorta occurs in 73.3 % of patients in this group. Predictors of vascular calcification is the age of patients and the duration of dialysis. With the progression of the degree of vascular calcification observed deterioration of bone mineral metabolism in the form of statistically significant increase in serum phosphorus, phosphorus-calcium product and parathyroid hormone. The plasma concentration of osteopontin correlates with the severity of abdominal aortic calcification and may be a marker of vascular calcification in dialysis patients.
https://doi.org/10.35339/ekm.2019.01.12
PDF (Русский)

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