Evaluation of nitrogen oxide metabolism and endothelin-1 synthesis in women with early termination of pregnancy at different gestational age
Vol 83 No 2 (2019), Gynecology
Vol 83 No 2 (2019)

Evaluation of nitrogen oxide metabolism and endothelin-1 synthesis in women with early termination of pregnancy at different gestational age

Gynecology
https://doi.org/10.35339/ekm.2019.83.02.11
Published March 13, 2020
S.V. Korovay
Kharkiv Medical Academy of Postgraduate Education
https://orcid.org/0000-0002-1590-3494
S.A. Stetsenko
Kharkiv National Medical University
https://orcid.org/0000-0003-2783-2694
A.V. Bondareva
Kharkiv National Medical University
https://orcid.org/0000-0003-1286-2962
PDF (Українська)

Keywords

premature birth
nitrogen oxide
endothelin-1
endothelial dysfunction

How to Cite

Korovay, S., Stetsenko, S., & Bondareva, A. (2020). Evaluation of nitrogen oxide metabolism and endothelin-1 synthesis in women with early termination of pregnancy at different gestational age. Experimental and Clinical Medicine, 83(2), 76-85. https://doi.org/10.35339/ekm.2019.83.02.11
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Abstract

The features of NO metabolism were studied and the level of endothelin-1 in the blood serum of women with early termination of pregnancy at different gestational ages was determined. 227 pregnant women enrolled in the Kharkov city perinatal center were examined. The formation of clinical groups was carried out depending on the duration of pregnancy in the form of premature and timely birth. The results of the study showed that in women with premature birth, endothelial dysfunction occurs with a shift in regulatory effects towards vasoconstrictors. The revealed changes in the nitrogen oxide metabolism and the synthesis of endothelin-1 in pregnant women indicate a violation of the adaptive-compensatory mechanisms and the possibility of promoting the development of preterm birth and the deterioration of the fetal condition.
https://doi.org/10.35339/ekm.2019.83.02.11
PDF (Українська)

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