Keywords
NR2 antibodies to NMDA receptors
vascular and intercellular adhesion molecules
pregabalin
How to Cite
Abstract
The article shows endothelium-vascular effects on the roots of the spinal cord with the progression of pain as a result of compression of the epidural microvascular plexus. In 68 patients with chronic low back pain before and after treatment were determined mediators of endothelium-vascular and axonal injuries, such as NR2-antibodies to NMDA microvascular receptors and the expression of soluble adhesion molecules of vascular endothelium-1 (sVCAM-1) and soluble intercellular adhesion molecules-1 (sICAM-1). All patients with low back pain showed an increase in the NR2 titer of antibodies to NMDA receptors and sVCAM-1 and sICAM-1 expression before treatment and a decrease in these parameters after treatment, especially in patients in the 2nd observation group. Thus, pregabalin at a dose of 150 mg in combination therapy convincingly influenced the reduction of neurovascular mediators and blocked neuropathic pain.References
Milevska–Vovchuk L.S. (2016). Vybir optymalnoho metodu otsinky bolovoho syndromu v patsiientiv iz khronichnym poperekovym bolovym syndromom [Choice of optimal method for pain assessment in patients with chronic low back pain]. Ukrainskyi nevrolohichnyi zhurnal – Ukrainian Neurological Journal, № 2, рр. 96–100. (in Ukrainian).
Novoseltsev S.V. (2010). Patogeneticheskie mekhanizmy formirovaniya poyasnichnykh spondilogennykh nevrologicheskikh sindromov u patsientov s gryzhami poyasnichnykh diskov [Pathogenetic mechanisms of the formation of lumbar spondylogenic neurologic syndromes in patients with lumbar disc herniae]. Manualnaya terapiya – Manual therapy, № 3 (39), рр. 77–82 (in Russian).
Sviridova N.K. (2016). Bol v spine kak chastaya prichina obrashcheniya k nevrologu. Etiologiya, patofiziologiya i lechenie boli [Back pain as a common reason for visiting a neurologist. Etiology, pathophysiology and treatment of pain]. Mezhdunarodnyy nevrologicheskiy zhurnal – International Neurological Journal, № 7 (85), рр. 78–80 (in Russian).
Shmagel A., Foley R., Ibrahim H. (2016). Epidemiology of chronic low back pain in us adults: data from the 2009–2010 national health and nutrition examination survey. Arthritis Care Res (Hoboken), vol. 68 (11), рр. 1688–1694.
Volkov A.V., Bolshakova G.B., Goldshteyn D.V. (2008). Morfologicheskie izmeneniya tkaney mezhpozvonkovykh diskov v statichnoy asimmetrichnoy kompressionnoy modeli degenerativno-distroficheskikh zabolevaniy mezhpozvonkovykh diskov [Morphological changes of intervertebral disc tissues in a static asymmetric compression model of degenerative-dystrophic diseases of intervertebral discs]. Byulleten eksperimentalnoy biologii i meditsiny –
Bulletin of Experimental Biology and Medicine, № 9, рр. 336–340 (in Russian).
Voloshyna N.P., Sukhorukov V.I., Fedosieiev S.V. et al. (2014). Suchasni pohliady na problemu bolovykh syndromiv u spyni ta shyi [Modern views on the problem of pain syndromes in the back and neck]. Materialy VII natsionalnoho konhresu «Liudyna ta liky – Ukraina» – Proceedings of the VII National Congress «Man and Medicine – Ukraine», Kyiv, p. 49 (in Ukrainian).
Andersen J.K. (2004). Oxidative stress in neurodegeneration: cause or consequence. Nature Reviews Neuroscience, № 10, рр. 18–25.
Podchufarova E.V., Yakhno N.N. (2013). Bol v spine [Backache]. Moskow: GEOTAR–Media, 372 р. (in Russian).
Pohorielov V.V., Bahmut I.Yu., Zhukov V.I. (2017). Strukturno-funktsionalni ta sudynni zminy pry formuvanni kompresiino-ishemichnoi radykulomiielopatii [Structural-functional and vascular changes in the formation of compressionischemic radiculomyelopathy]. Ekperymentalna i klinichna medytsyna – Experimental and clinical medicine, № 3 (76), рр. 47–52 (in Ukrainian).
Svistilnik T.V. (2013). Fenomen eksaitotoksychnosti. Mekhanizmy vynyknennia, znachennia v rozvytku neironalnoho poshkodzhennia ta mozhlyvosti yoho korektsii pry patolohiiakh TsNS [Phenomenon exitotoxicity. Occurrence mechanisms, value in development neuronal of damage and possibility of its correction at pathologies CNS]. Biomedical and biosocial anthropology, № 20, рр. 207–215 (in Ukrainian).
Davydova O.N. (2007). Issledovanie NMDA-retseptorov limfotsitov cheloveka [Characterization of NMDA-receptors in human lymphocytes]. Аvtoreferat. Moskow, 21 р. (in Russian).
Kukushkin M.L. (2011). Neyrofiziologiya boli i obezbolivaniya [Neurophysiology of pain and anesthesia]. Bol. Sustavy. Pozvonochnik – Pain. Joints. Spine, № 20, рр. 60–65 (in Russian).
Kalia L.V., Kalia S.K., Salter M.W. (2008). MNDA receptors in clinical neurology: excitatory times ahead. Lancet Neurol., № 7, рр. 742–75
Melnikova Yu.S., Makarova T.P. (2015). Endotelialnaya disfunktsiya kak tsentralnoe zveno patogeneza khronicheskikh bolezney [Endothelial dysfunction as the key link of chronic diseases pathogenesis]. Kazanskiy meditsinskiy zhurnal – Kazan Medical Journal, № 96 (4), рр. 659–665 (in Russian).
Goryacheva M., Shumakher G., Kostyuchenko L., Tsybirova L., Veselovsky P., Fedyanin S. et al. (2014). Biochemical characteristics of distal vessels endothelium in patients with syndroms of lumbosacral radiculopathies and others neurological syndroms lumbar osteochondrosis in recrudescence phase. Advances in Biochemistry, № 2 (6), 95–102.
Heviak O.M., Kuzminskyi A.P. (2017). Porushennia spinalnoho krovoobihu [Disorders of spinal blood circulation]. Mizhnarodnyi nevrolohichnyi zhurnal – International Neurological Journal, № 5 (91), рр. 81–86 (in Ukrainian).
Semenova A.V., Ivanova M.F., Sunichuk N.N., Glazovskaya I.I. (2017). Pregabalin pri boli v nizhney chasti spiny [Pregabalin in low back pain]. Mizhnarodnyi nevrolohichnyi zhurnal – International Neurological Journal, № 3 (89), рр. 53–59 (in Russian).