Compression-ischemic endothelial dysfunction as a central part of the development of chronic neuropathic pain and neurodestruction of the spinal roots
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Keywords

compression of the epidural microvascular plexus
NR2 antibodies to NMDA receptors
vascular and intercellular adhesion molecules
pregabalin

How to Cite

Pogorelov, V., Bagmut, I., & Zhukov, V. (2020). Compression-ischemic endothelial dysfunction as a central part of the development of chronic neuropathic pain and neurodestruction of the spinal roots. Experimental and Clinical Medicine, 83(2), 69-75. https://doi.org/10.35339/ekm.2019.83.02.10

Abstract

The article shows endothelium-vascular effects on the roots of the spinal cord with the progression of pain as a result of compression of the epidural microvascular plexus. In 68 patients with chronic low back pain before and after treatment were determined mediators of endothelium-vascular and axonal injuries, such as NR2-antibodies to NMDA microvascular receptors and the expression of soluble adhesion molecules of vascular endothelium-1 (sVCAM-1) and soluble intercellular adhesion molecules-1 (sICAM-1). All patients with low back pain showed an increase in the NR2 titer of antibodies to NMDA receptors and sVCAM-1 and sICAM-1 expression before treatment and a decrease in these parameters after treatment, especially in patients in the 2nd observation group. Thus, pregabalin at a dose of 150 mg in combination therapy convincingly influenced the reduction of neurovascular mediators and blocked neuropathic pain.
https://doi.org/10.35339/ekm.2019.83.02.10
PDF (Українська)

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