Keywords
endogenous intoxication
thyroid dysfunction
How to Cite
Abstract
The indices of endogenous intoxication in the serum and periodontal homogenate of rats with periodontitis without comorbidity and against the background of hyper- and hypothyroidism were studied. Experimental periodontitis is accompanied by an increase in the level of endogenous intoxication, as indicated by an increase in the content of middle mass molecules. When comparing the dynamics of changes in the indices of endogenous intoxication, their synchronous development at the systemic and local levels was revealed. An imbalance of thyroid hormones increases endogenous intoxication in experimental periodontitis, especially pronounced in hyperthyroidism.References
Sidelnikova L.F., Skibitskaya E.A., Mulkovsky K.O. (2014). Kompleksnaya dezintoksikatsionnaya terapiya generalizovannogo parodontita v period obostreniya [Comprehensive detoxification therapy of generalized periodontitis in the period of exacerbation]. Sovremennaya Stomatologiya – Modern Dentistry, vol. 5. pp. 23–26 [in Russian].
Sакvarelidze I. (2014). Rol svobodno-radikalnogo okisleniia i antioksidantnoi zashchity v razvitii vospalitelnykh protcessov v parodonte v zhenskoi populiatcii [The role of free radical oxidation and antioxidant protection in the development of inflammatory processes in the periodontium in the female population]. Aktualnye Voprosy Zhenskogo Zdorovia – Actual issues of women's health, vol. 5, pp. 64–76 [in Russian].
Uspenskaya O.A., Kachesova E.S. (2017). Izmeneniya biokhimicheskikh pokazateley krovi pri lechenii bystroprogressiruyushchego parodontita [The changes in blood biochemical parameters in the treatment of rapidly progressive periodontitis]. Problemy stomatologii – Dental problems, vol.13 (2), pp. 33–38 [in Russian].
Shcherba V.V., Krynytska I.Ya., Korda M.M. (2018). Zminy funktsional`noho stanu systemy syntezu hidrohen sul`fidu u shchuriv z parodontytom na foni hiper- ta hipotyreozu [The changes in the functional state of the hydrogen sulfide synthesis system in rats with periodontitis on the background of hyperthyroidism and hypothyroidism]. Eksperymentalna i klinichna medytsyna – Experimental and Clinical Medicine, vol. 4 (81), pp. 25–31 [in Ukrainian].
Savel'yeva N.N. (2015). Sostoyaniye sistemy perekisnogo okisleniya lipidov i antioksidantnoy zashchity u bol'nykh khronicheskim generalizovannym parodontitom I-II stepeni tyazhesti, sochetayushchegosya s parazitozami [The state of the system of lipid peroxidation and antioxidant protection in patients with chronic generalized periodontitis I-II severity, combined with parasitosis]. Journal of Education, Health and Sport, vol. 5 (12), pp. 465–476 [in Russian].
Kondyurova Ye.V., Prytkov V.A., Vlasov A.P., Trofimov V.A., Adamchik R.A. (2016). Metabolicheskiye narusheniya pri khronicheskom generalizovannom parodontite [Metabolic disorders in chronic generalized periodontitis]. Rossiyskiy stomatologicheskiy zhurnal – Russian Dental Journal, vol. 20 (5), pp. 251–256 [in Russian].
Payenok O.S., Kostiv M.O. (2012). Protsesy peroksydnoho okysnennya lipidiv i riven` endohennoyi intoksykatsiyi u vahitnykh iz tyreopatiyamy [The processes of peroxide oxidation of lipids and the level of endogenous intoxication in pregnant women with thyropathies]. Eksperymental`na ta klinichna fiziolohiya ta biokhimiya – Experimental and clinical physiology and biochemistry, vol. 1, pp. 97–101 [in Ukrainian].
Hryh N.I. (2015). Endohenna intoksykatsiya yak faktor ryzyku v kompleksnomu likuvanni heneralizovanoho parodontytu [Endogenous intoxication as a risk factor in the complex treatment of generalized periodontitis]. Sovremennaya Stomatologiya – Modern Dentistry, vol. 1, pp. 28–31 [in Ukrainian].
Mamontova T.V., Vesnina L.E., Kaydashev I.P. (2014). Mikroflora rotovoy polosti kak faktor razvitiya zabolevaniy serdechno-sosudistoy sistemy [Oral microflora as a factor in the development of diseases of the cardiovascular system]. Ukr. med. chasopys: nauk.-prakt. Zahalnomed. chasopys. – Ukr Med. Journal: Sciences. Pract. general medicine a magazine, vol. 4, pp.186–192 [in Russian].
Savchuk Z.L. (2015). Pokaznyky endohennoyi intoksykatsiyi u kroliv z khimichnym opikom rohivky na tli merkazolil-indukovanoho hipotyreozu [The indices of endogenous intoxication in rabbits with chemical burn of the cornea against the background of Mercazolil-induced hypothyroidism]. Svit medytsyny ta biolohiyi – World of Medicine and Biology, vol. 2 (49), pp.166–171 [in Ukrainian].
Reheda M.S., Shchepanskyy F.Y., Shchepanskyy B.F. (2018). Osoblyvosti zmin endohennoyi intoksykatsiyi za umov rozvytku eksperymentalnoyi bronkhialnoyi astmy pry khronichnomu parodontyti ta korektsiya yikh tiotryazolinom [Features of changes of endogenous intoxication under conditions of development of experimental bronchial asthma during chronic periodontitis and correction by their tiotriazolinom]. Odeskyy medychnyy zhurnal – Odessa Medical Journal, vol. 4 (168), pp. 18–21 [in Ukrainian].
Avdyeyev O.V., Boykiv A.B. (2011). Stan endohennoyi intoksykatsiyi u tvaryn iz zapalennyam u parodonti za zminenoyi reaktyvnosti [The state of endogenous intoxication in animals with inflammation in a periodontium with altered reactivity]. Medychna i klinichna khimiya – Medical and clinical chemistry, vol. 1 (13), pp.126–129 [in Ukrainian].
Danilova I.G., Gette I.F., Abidov M.T., Kisel'nikova L.P., Yushkov B.G., Sharapova N.Ye., Gos'kov I.A. (2007). Sostoyaniye immunnoy sistemy i endogennaya intoksikatsiya pri eksperimentalnom parodontite [The state of the immune system and endogenous intoxication in experimental periodontitis]. Sibirskoye meditsinskoye obozreniye – Siberian Medical Review, vol. 3, pp. 29–33 [in Russian].
Moiseeva E.G. (2008). Metabolicheskii gomeostaz i imunnaia reaktivnost organizma v dinamike vospaleniia v tkaniakh parodonta (eksperimentalnoe issledovanie) [Metabolic homeostasis and the body's immune reactivity in the dynamics of inflammation in periodontal tissues (experimental study)]. Doctor`s tesis. Moskva: Rossiiskii Universitet druzhby narodov. 45 [in Russian].
Ratushnenko V.O. (2010). Funktcіonalna rol tіol-disulfіdnoї sistemi pri eksperimentalnomu gіpo- і gіpertireozі [Functional role of thiol-disulphide system in experimental hypo- and hyperthyroidism]. Odeskii medichnii zhurnal – Odessa Medical Journal, vol. 2 (118), pp. 17–20 [in Russian].
European convention for the protection of vertebrate animals used for experimental and other scientific purposes (1986). Council of Europe. Strasbourg. № 123, р. 52.
Radchenko O.M., Kondratyuk M.O. (2009). Syndrom endohennoyi intoksykatsiyi v klinitsi vnutrishnikh khvorob (ohlyad literatury ta vlasni sposterezhennya) [Endogenous intoxication syndrome in the clinic of internal diseases (literature review and own observations)]. Medychna hidrolohiya ta reabilitatsiya – Medical hydrology and rehabilitation, vol. 7 (3), pp. 25–32 [in Ukrainian].
Lifshits R.I., Val'dman B.M., Volchegorskiy I.A., Luzhevskiy A.S. (1986). Rol srednemolekulyarnykh peptidov krovi v razvitii kardiodepresii pri termicheskikh ozhogag [The Role of Medium Molecular Peptides in the Development of Cardiodepression during Thermal Burns]. Byul. eksperim. biol. i meditsiny – Bull. experiment biol. and medicine, vol. 101 (3), pp.280–282 [in Russian].
Pylypchuk T.P., Krynytska I.Ya. (2019). Doslidzhennya pokaznykiv endohennoyi intoksykatsiyi u shchuriv v dynamitsi rozvytku syndromu tryvaloho stysnennya [Investigation of indices of endogenous intoxication in rats in the dynamics of development of syndrome of long-term compression]. Visnyk problem biolohiyi i medytsyny – Bulletin of Biology and Medicine, vol. 2 (149), pp. 171–175 [in Ukrainian].
Malakhova M.Ya. (2000). Endogennaia intoksikatciia kak otrazhenie kompensatornoi perestroiki obmennykh protcessov v organizme [Endogenous intoxication as a reflection of compensatory restructuring of metabolic processes in the body]. Efferentnaia terapiia – Efferent therapy, vol. 6 (4), pp. 3–14 [in Russian].
Obukhova L.M., Andriyanova N.A. (2014). Opredeleniye veshchestv nizkoy i sredney molekulyarnoy massy v syvorotke krovi kak dopolnitel'nyy diagnosticheskiy kriteriy pri smertelnykh otravleniyakh narkoticheskimi veshchestvami [Determination of substances of low and medium molecular weight in serum as an additional diagnostic criterion for fatal poisoning with narcotic substances]. Sudebno-meditsinskaya ekspertiza – Forensic-medical examination, vol. 6, pp. 37–39 [in Russian].
Sidelnikova V.I., Chernitskiy A.Ye., Retskiy M.I. (2015). Endogennaya intoksikatsiya i vospaleniye: posledovatelnost reaktsiy i informativnost markerov [Endogenous intoxication and inflammation: the sequence of reactions and the information content of markers]. Selskokhozyaystvennaya biologiya – Agricultural biology, vol. 50 (2), pp. 152–161 [in Russian].