Keywords
placental lactogen
estradiol
oxytocinase
progesteron
How to Cite
Abstract
In press
Placental insufficiency is a complex of symptoms that occur during pregnancy due to impaired placental functions, which is an initial step of pathogenesis in many complications of gestation, namely fetal growth restriction, preeclampsia, premature birth, miscarriage. The key function of the placenta is endocrine, which is provided by the production of such hormones as placental lactogen, progesterone, estradiol, chorionic gonadotropin, and the enzyme oxytocinase, etc., which are responsible for preservation of pregnancy. Since there is still no reliable effective therapy for this condition, the aim of the study was to find one of the pathogenetic methods of treatment, namely, to determine the effect of hyperbaric oxygenation courses added to the complex therapy of placental insufficiency on the endocrine function of the placenta. This is a prospective case-control study in which 105 pregnant women participated, at gestational ages from 16 to 22 weeks. The women were divided into three groups. The control group consisted of 40 women with a physiological course of pregnancy. Group IIa included 35 women who had signs of early placental insufficiency and received standard treatment, group IIb consisted of 30 women who were diagnosed with placental insufficiency and as part of complex therapy, they also received courses of hyperbaric oxygenation. All women before treatment and 7–10 days after its completion were measured the content of hormones in the blood: progesterone, estradiol, chorionic gonadotropin, placental lactogen and oxytocinase. During the study, it was determined that the content of placental hormones before treatment was lower than reference values in women from groups IIa and IIb, compared to the control group. And after therapy, hormone levels increased more significantly almost to physiological level in the group where women also received courses of hyperbaric oxygenation than in group IIa.
Keywords: placental insufficiency, placental lactogen, estradiol, oxytocinase, progesteron.
References
Ohgiya Y, Nobusawa H, Seino N, Miyagami O, Yagi N, Hiroto S, et al MR Imaging of Fetuses to Evaluate Placental Insufficiency. Magn Reson Med Sci. 2016;15(2):212-9. DOI: 10.2463/mrms.mp.2015-0051. PMID: 26607809.
Seliukova NYu, Misyura KV. Experimental models of fetoplaceental insufficiency in animals (literature review and own observations). Problems of Endocrine Pathology. 2019;4:130-9. DOI: 10.21856/j-PEP.2019.4.18. [In Ukrainian].
Hsieh YC, Kao TC, Yang IJ, Yang PK, Chao KH, Chen MJ, et al. Association between estradiol levels in early pregnancy and risk of preeclampsia after frozen embryo transfer. Front Endocrinol (Lausanne). 2023;14:1223181. DOI: 10.3389/fendo.2023.1223181. PMID: 37795369.
He WH, Jin MM, Liu AP, Zhou Y, Hu XL, Zhu YM, Liu AX. Estradiol promotes trophoblast viability and invasion by activating SGK1. Biomed Pharmacother. 2019;117:109092. DOI: 10.1016/j.biopha.2019.109092. PMID: 31203134.
Baud O, Berkane N. Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment. Front Endocrinol (Lausanne). 2019;10:179. DOI: 10.3389/fendo.2019.00179. PMID: 30972026.
Okada H, Tsuzuki T, Murata H. Decidualization of the human endometrium. Reprod Med Biol. 2018;17(3):220-7. DOI: 10.1002/rmb2.12088. PMID: 30013421.
Bulletti C, Bulletti FM, Sciorio R, Guido M. Progesterone: The Key Factor of the Beginning of Life. Int J Mol Sci. 2022;23(22):14138. DOI: 10.3390/ijms232214138. PMID: 36430614.
Gridelet V, Perrier d'Hauterive S, Polese B, Foidart JM, Nisolle M, Geenen V. Human Chorionic Gonadotrophin: New Pleiotropic Functions for an "Old" Hormone During Pregnancy. Front Immunol. 2020;11:343. DOI: 10.3389/fimmu.2020.00343. PMID: 32231662;|
Schumacher A. Human Chorionic Gonadotropin as a Pivotal Endocrine Immune Regulator Initiating and Preserving Fetal Tolerance. Int J Mol Sci. 2017;18(10):2166. DOI: 10.3390/ijms18102166. PMID: 29039764.
Rassie K, Giri R, Joham AE, Teede H, Mousa A. Human Placental Lactogen in Relation to Maternal Metabolic Health and Fetal Outcomes: A Systematic Review and Meta-Analysis. Int J Mol Sci. 2022;23(24):15621. DOI: 10.3390/ijms232415621. PMID: 36555258.
Klimek R. Oxytocinase as the most important marker of fetal development. Early Pregnancy (Cherry Hill). 2001;5(1):38-9. PMID: 11753505.
Dall'Asta A, Melito C, Morganelli G, Lees C, Ghi T. Determinants of placental insufficiency in fetal growth restriction. Ultrasound Obstet Gynecol. 2023;61(2):152-7. DOI: 10.1002/uog.26111. PMID: 36349884.
Wardinger JE, Ambati S. Placental Insufficiency. [Updated 2022 Oct 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK563171/
Huang ET, Mansouri J, Murad MH, Joseph WS, Strauss MB, Tettelbach W, Worth ER; UHMS CPG Oversight Committee. A clinical practice guideline for the use of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers. Undersea Hyperb Med. 2015;42(3):205-47. PMID: 26152105.
Fu Q, Duan R, Sun Y, Li Q. Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics. Redox Biology. 2022 ;53:102352. DOI: 10.1016/j.redox.2022.102352. PMID: 35649312.
Piantadosi C. Physiology of hyperbaric hyperoxia. Respir Care Clin N Am. 1999;5(1):7-19, v. PMID: 10205811.
Shinomiya N. Molecular Mechanisms of Hyperbaric Oxygen Therapy. In: Shinomiya N, Asai Y (eds). Hyperbaric Oxygenation Therapy. Singapore: Springer; 2020. DOI: 10.1007/978-981-13-7836-2_1.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.