Study of risk factors for insulin resistance in women with a burdened metabolic history

Abstract

In press

Insulin Resistance (IR) is a state of insufficient biological response of the body's cells to insulin, which leads to further disruption of carbohydrate metabolism and increased blood glucose levels. Early detection of IR risk factors improves the prognosis and prevention of severe metabolic syndrome, preservation and restoration of women's reproductive potential, and becomes the foundation for the health of the future generation. Aim of the study was the influence of potential risk factors on the development of latent IR manifestations 82 women of early reproductive age who signed an informed consent for the study were examined. A specially designed questionnaire was used for the study, and anthropometric parameters and laboratory data (including insulin, glucose tolerance test), and calculation of indices (HOMA-IR (Homeostasis Model Assessment of Insulin Resistance) and Matsuda). According to the results of the study, in accordance with the indicators of Relative Risk (RR) and Odds Ratio (OR), we consider the following potential factors to be developmental bad habits (tobacco smoking regardless of the amount, regular alcohol abuse) (RR=1.299; p=0.00321), burdened hereditary history of cardiovascular diseases (essential hypertension, heart attacks and strokes) (RR=1.313; p=0.0041), type I and type II diabetes mellitus (RR=1.340; p=0.0038), obesity (RR=1.641; p=0.0043), thyroid diseases (hypothyroidism, hyperthyroidism, hyperparathyroidism) (RR=1.565; RR=1.565; p=0.00284) and adrenal (Itzen-Cushing's syndrome, adrenal cortex insufficiency) (RR=1.348; p=0.0025). The manifestations of IR should be skin rashes (OR=3.542; p=0.0033) and unwanted hair growth (OR=3.670; p=0.0029).

Keywords: overweight, obesity, metabolic syndrome, vaginal microbiome, ovulation, infertility.