Keywords
ointments and gels
wound-healing effect
antioxidant and cytoprotective activity
How to Cite
Abstract
The problem of treatment of burn wounds in Ukraine and in the world was shown. Every year in Ukraine more than 20,000 adults and 10,000 children need inpatient treatment for burn wounds. The frequency of burn injuries in the developed countries of the world reaches one per 1 thousand population. In the USA about 200,000 people get burns every year, half of them require hospitalization. In Great Britain, about 250,000 people receive care every year, of which 175,000 people sought emergency inpatient care. One of the means of conservative treatment of burn wounds is soft medicinal forms in the form of ointments, creams, gels, balms, etc. with wound-healing, antiseptic and/or antimicrobial properties. Analysis of the nomenclature of soft medicinal forms for the treatment of burn wounds, which are using in Ukraine, shows that none of them contain quercetin. Significant interest of researchers in the study of the local wound-healing effect of quercetin and its mechanisms has been demonstrated. Demonstrated the flavonoid quercetin is found in many plants and has proven broad pharmacodynamics due to the peculiarities of the molecular structure. The quercetin molecule contains a phenolic group and double bonds that bind free radicals, transition metal ions, which affects the processes of oxidation and phosphorylation. Thanks to this, quercetin exhibits powerful antioxidant, membrane stabilizing and cytoprotective effects, which play a significant role in the mechanism of antioxidant, anti-inflammatory, antiallergic, antimicrobial and reparative action. This provides a significant wound-healing activity of quercetin in the local treatment of the wound process due to atopic dermatitis, eczema, cold and thermal burns. The conducted analysis and generalization substantiate the relevance, expediency and timeliness of the search and creation of new soft forms of medicines containing quercetin for the treatment of burn wounds.
Keywords: flavonoid quercetin, ointments and gels, wound-healing effect, antioxidant and cytoprotective activity.
Archived: https://doi.org/10.5281/zenodo.14023830
References
Zaporozhan SY, Tuzyuk NV. Treatment of burns using xenotransplants, saturated with nanocrystals of silver. Bulletin of Medical and Biological Research. 2021;3(9):24-8. DOI: 10.11603/bmbr.2706-6290.2021.3.12562. [In Ukrainian].
Lynnyk OM, Kozynets GP. Application of ethylmethylhydroxypyridine succinate in patients with the burns. The Ukrainian Journal of Clinical Surgery. 2023;90(2):29-33. DOI: 10.26779/2786-832X.2023.2.29. [In Ukrainian].
Borysiuk IU, Dyadyk AA, Kissa MV, Valivodz IP. Justification of the use of plant extracts in the creation of new medicinal forms of anti-burn effect.: Proceedings of the 10th International scientific and practical conference "Modern research in world science" (Ukraine, Lviv, 25–27 Dec 2022). P. 257-64. Available at: https://sci-conf.com.ua/x-mizhnarodna-naukovo-praktichna-konferentsiya-modern-research-in-world-science-25-27-12-2022-lviv-ukrayina-arhiv [in Ukrainian].
Vons BV, Grochovuy TA. Pharmacological grounds for the selection of active pharmaceutical ingredients for the local treatment of burns on the aseptic burn wounds model in rats. Medical and Clinical Chemistry. 2019;21(1):55-62. DOI: 10.11603/mcch.2410-681X.2019.v0.i1.9831. [In Ukrainian].
Roik OМ, Nikitina OО. Justification of the composition and technology of the gel for the treatment of wounds and burns with sage medicinal extract. techeng 2022;6(11):89-103. Available at: https://vistnuk.knutd.edu.ua/wp-content/uploads/sites/2/2022/12/9-6-2022.pdf [in Ukrainian].
Basarab YaO, Netyukhailo LH. Effects of liposomal form of phosphatidylcholine on oxidative-nitrosative stress in renal tissues of rats in burn disease. Journal of Education, Health and Sport. 2020;10(10):191-200. DOI: 10.12775/JEHS.2020.10.10.017.
Balyuk OE. Modern principles of use of antioxidants in dermatology. Materials of the scientific and practical conference with international participation, dedicated to the 70th anniversary of the birth of Professor VM Bobirev "Modern aspects of free radical pathology in experimental and clinical medicine" (Ukraine, Poltava, 7–8 May 2020). P. 46-7. Available at: http://repository.pdmu.edu.ua/handle/123456789/14338 [in Ukrainian].
Iermolenko TI, Shapoval OM, Chorna NS. Prospects for treatment of skin burns with preparations containing food plant extracts. Collection of materials of the scientific conference "Current issues of dermatology, venereology and HIV/AIDS infection" (Ukraine, Kharkiv, 10–11 Nov 2020). Ed. Dashchuk AM. P. 57-63. Available at: https://repo.knmu.edu.ua/handle/123456789/27234 [in Ukrainian].
Iermolenko TI, Chorna NS, Shapoval OM. Theoretical justification of the search for potential medicinal products containing food plant biologically active substances. Clinical Pharmacy. 2019;23(2):30-8. DOI: 10.24959/cphj.19.1490.
Larionov VB, Tsisak AO, Eberle LV, Bieniet SS. Adaptogenic effect of the gels with Cetraria islandica L. extract on the regenerative properties of the skin in thermal burn mode. Pharmacology and Drug Toxicology. 2022;16(4):240-7. DOI: 10.33250/16.04.240. [In Ukrainian].
Compendium. Specialized medical online publication for doctors, pharmacists, students of medical and pharmaceutical universities. Available at: https://compendium.com.ua/uk [in Ukrainian].
Azeem M, Hanif M, Mahmood K, Ameer N, Chughtai FRS, Abid U. An insight into anticancer, antioxidant, antimicrobial, antidiabetic and anti-inflammatory effects of quercetin: a review. Polym Bull (Berl). 2023;80(1):241-62. DOI: 10.1007/s00289-022-04091-8. PMID: 35125574.
Alizadeh SR, Ebrahimzadeh MA. Quercetin derivatives: Drug design, development, and biological activities, a review. European Journal of Medicinal Chemistry. 2022;229:114068. DOI: 10.1016/j.ejmech.2021.114068. PMID: 34971873.
D'Andrea G. Quercetin: A flavonol with multifaceted therapeutic applications? Fitoterapia. 2015;106:256-71. DOI: 10.1016/j.fitote.2015.09.018. PMID: 26393898.
Qi W, Qi W, Xiong D, Long M. Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy.Molecules. 2022;27(19):6545. DOI: 10.3390/MOLECULES27196545.
Polera N, Badolato M, Perri F, Carullo G, Aiello F. Quercetin and its Natural Sources in Wound Healing Management. Curr Med Chem. 2019;26(31):5825-48. DOI: 10.2174/0929867325666180713150626. PMID: 30009700.
Beken B, Serttas R, Yazicioglu M, Turkekul K, Erdogan S. Quercetin Improves Inflammation, Oxidative Stress, and Impaired Wound Healing in Atopic Dermatitis Model of Human Keratinocytes. Pediatr Allergy Immunol Pulmonol. 2020;33(2):69-79. DOI: 10.1089/ped.2019.1137. PMID: 34678092.
Liu C, Cheng X, Wu Y, Xu W, Xia H, Jia R, et al. Antioxidant Activity of Quercetin-Containing Liposomes-in-Gel and Its Effect on Prevention and Treatment of Cutaneous Eczema. Pharmaceuticals (Basel). 2023;16(8):1184. DOI: 10.3390/ph16081184. PMID: 37631099.
Zhou L, Cai L, Ruan H, Zhang L, Wang J, Jiang H, et al. Electrospun chitosan oligosaccharide/polycaprolactone nanofibers loaded with wound-healing compounds of Rutin and Quercetin as antibacterial dressings. Int J Biol Macromol. 2021;183:1145-54. DOI: 10.1016/j.ijbiomac.2021.05.031. PMID: 33965491.
Irfan F, Jameel F, Khan I, Aslam R, Faizi S, Salim A. Role of quercetin and rutin in enhancing the therapeutic potential of mesenchymal stem cells for cold induced burn wound. Regen Ther. 2022;21:225-38. DOI:10.1016/j.reth.2022.07.011. PMID: 36092499.
Panthi VK, Imran M, Chaudhary A, Paudel KR, Mohammed Y. The significance of quercetin-loaded advanced nanoformulations for the management of diabetic wounds. Nanomedicine (Lond). 2023;18(4):391-411. DOI: 10.2217/nnm-2022-0281. PMID: 37140389.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.