Clinical aspects of usage of neutrophil-to-lymphocyte ratio in cardiology: literature review and own data
Vol 87 No 2 (2020), Therapy
Vol 87 No 2 (2020)

Clinical aspects of usage of neutrophil-to-lymphocyte ratio in cardiology: literature review and own data

Therapy
https://doi.org/10.35339/ekm.2020.87.02.04
Published October 1, 2020
L.M. Strilchuk
Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
https://orcid.org/0000-0001-7077-2610
A.L. Filipyuk
Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
https://orcid.org/0000-0001-6641-0780
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Keywords

neutrophils to lymphocyte ratio
ischemic heart disease
inflammation
survival
prognosis

How to Cite

Strilchuk, L., & Filipyuk, A. (2020). Clinical aspects of usage of neutrophil-to-lymphocyte ratio in cardiology: literature review and own data. Experimental and Clinical Medicine, 87(2), 27-35. https://doi.org/10.35339/ekm.2020.87.02.04
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Abstract

We analyzed the data of 197 patients with IHD, unstable (116) and stable (81) angina pectoris, and also prospective data 121 patient with chronic IHD (3 years of follow-up). We included 20 healthy volunteers for reference values. Digital data was statistically processed. According to literature data, NLR can serve as a prognostic marker of cardiovascular disease course. Its level depends on nosology; its increase is an independent predictor of IHD, higher mortality level, repeated inpatient treatment, atrial fibrillation, insufficient efficiency of invasive cardiologic procedures. NLR also correlates with heart failure class, left ventricle hypertrophy, tendency to hypercoagulation, inflammation level. NLR was higher in patients with acute forms of IHD [2.91 vs 2.47; significantly higher than in healthy patients (1.80)]. NLR correlated with inflammation level (according to leucocytes, erythrocyte sedimentation rate, C-reactive protein, seromucoids, total fibrinogen), glucose, (3-lipoproteids, de Ritis index, creatinine and urea, and also with sizes of both ventricles and left atrium. Patients with NLR>3 were characterized by significantly more frequent arrhythmias [odds ratio 2.93 (95% confidence interval 1.05-8.19)] and higher heart rate, activation of inflammation and endogenous intoxication. In stable IHD NLR >3 was accompanied by significantly worse 3 years' prognosis. NLR can be considered a prognostic marker of cardiovascular diseases course. It correlates with inflammation level, glucose, (3-lipoproteids, de Ritis index, creatinine, urea, and also both ventricles and left atrium. NLR is a simple informative method of prognosis in cardiology with a breaking point of 3.0, which does not involve the increase of investigations of inpatients and outpatients.

Keywords: neutrophils to lymphocyte ratio, ischemic heart disease, inflammation, survival, prognosis.

https://doi.org/10.35339/ekm.2020.87.02.04
PDF (Українська)

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