Ключові слова
харчування дитини
харчування матері
мікробіоценоз
програмування здоров'я
дитяча нутриціологія
Як цитувати
Анотація
In press
Актуальність. В останні роки в дитячій популяції суттєво збільшилась кількість захворювань, профіль яких все частіше відповідає «дорослому типу». Лише [3–5] % дітей старшого шкільного віку в Україні можуть вважатися здоровими. На здоров’я дітей впливає низка шкідливих факторів навколишнього середовища, інфекції, стрес. Основи здоров’я дитини закладаються ще до її народження. Програмування довгострокового здоров'я триває до 2–3 років, коли формується кишковий мікробіом, що є модулятором метаболізму, поведінкових реакцій, роботи імунної та нервової систем. Дані про кишковий мікробіом численні, проте недостатньо систематизовані.
Мета. Проаналізувати сучасні наукові джерела щодо впливу харчування на формування мікробіому дитини як фактора програмування довгострокового здоров'я.
Матеріали та методи. Дослідження проведено з використанням бібліосематичного методу та системного аналізу. Пошук наукових джерел проведено в наукометричних базах PubMed, Scopus, Web of Science, Google Scholar, Wiley Online Library за 2015–2026 рр. До аналізу включено 121 джерело. Дослідження проведено в межах науково-дослідної роботи кафедр педіатричного профілю Харківського національного медичного університету «Медико-біологічні аспекти адаптації дітей з соматичною патологією в сучасних умовах» (2023–2026), номер державної реєстрації 0123U101768.
Етика дослідження. В ході роботи були відібрані літературні джерела, що описують дослідження, автори яких дотримувалися сучасних біоетичних норм.
Результати. Аналіз джерел показав, що збалансоване повноцінне харчування під час вагітності та на ранніх стадіях життя дитини відіграє ключову роль у формуванні кишкової мікробіоти дитини, яка є важливим фактором фізичного та нейропсихічного здоров’я, сприяє формуванню та дозріванню імунної системи. Харчування матері під час вагітності та дитини в перші роки життя може порушити цей процес. Неналежне формування кишкового мікробіому може негативно впливати на фізичний розвиток дитини, спричинити появу метаболічних, серцево-судинних, аутоімунних, алергічних та нейродегенеративних захворювань, діабету 2-го типу навіть у дорослому віці. Грудне вигодовування, своєчасне введення прикорму, застосування харчових втручань можуть допомогти створити здорову мікробіоту дитини з народження і таким чином «запрограмувати» довгострокове здоров'я.
Висновки. Формування здорового мікробіому має вирішальне значення для розробки цілеспрямованих харчових втручань з метою покращення здоров'я протягом усього життя.
Ключові слова: педіатрія і неонатологія, харчування дитини, харчування матері, мікробіоценоз, програмування здоров'я, дитяча нутриціологія.
Посилання
Mikkelsen B, Williams J, Rakovac I, Wickramasinghe K, Hennis A, Shin HR, et al. Life course approach to prevention and control of non-communicable diseases. BMJ. 2019;364:1257. DOI: 10.1136/bmj.l257. PMID: 30692103.
Fontaine F, Turjeman S, Callens K, Koren O. The Intersection of Undernutrition, Microbiome, and Child Development in the First Years of Life. Nature communications. 2023;14(1):3554. DOI: 10.1038/s41467-023-39285-9. PMID: 37322020.
Robertson RC, Manges AR, Finlay BB, Prendergast AJ. The Human Microbiome and Child Growth – First 1000 Days and Beyond. Trends in Microbiology. 2019;27(2):131-47. DOI: 10.1016/j.tim.2018.09.008. PMID: 30529020.
Wagner CL. Convergence of Two Fields-Breastfeeding and Lifestyle Medicine: Integrating Early Nutrition and Wellness for Lifelong Outcomes: A Tribute to Dr. Ruth Lawrence, A Pioneer in Both Fields. Breastfeed Med. 2025;20(3):163-9. DOI: 10.1089/bfm.2025.0003. PMID: 39949286.
Barratt MJ, Ahmed T, Gordon JI. Gut microbiome development and childhood undernutrition. Cell Host Microbe. 2022;30(5):617-26. DOI: 10.1016/j.chom.2022.04.002. PMID: 35550665.
United Nations Children’s Fund (UNICEF), World Health Organization (WHO), International Bank for Reconstruction and Development/The World Bank. Levels and trends in child malnutrition: UNICEF / WHO / World Bank Group Joint Child Malnutrition Estimates: Key findings of the 2023 edition. New York: UNICEF and WHO; 2023. 32 p. Available at: https://data.unicef.org/wp-content/uploads/2023/05/JME-2023-Levels-and-trends-in-child-malnutrition.pdf
Sasidharan Pillai S, Gagnon CA, Foster C, Ashraf AP. Exploring the Gut Microbiota: Key Insights into Its Role in Obesity, Metabolic Syndrome, and Type 2 Diabetes. J Clin Endocrinol Metab. 2024;109(11):2709-19. DOI: 10.1210/clinem/dgae499. PMID: 39040013.
Van Hul M, Cani PD. The gut microbiota in obesity and weight management: microbes as friends or foe? Nat Rev Endocrinol. 2023;19(5):258-71. DOI: 10.1038/s41574-022-00794-0. PMID: 36650295.
Bonder MJ, Tigchelaar EF, Cai X, Trynka G, Cenit MC, Hrdlickova B et al. The influence of a short-term gluten-free diet on the human gut microbiome. Genome Med. 2016;8(1):45. DOI: 10.1186/s13073-016-0295-y. PMID: 27102333.
Rothschild D, Weissbrod O, Barkan E, Kurilshikov A, Korem T, Zeevi D, et al. Environment dominates over host genetics in shaping human gut microbiota. Nature. 2018;555(7695):210-5. DOI: 10.1038/nature25973. PMID: 29489753.
Zou L, Zhang Z, Chen J, Guo R, Tong X, Ju Y, et al. Unraveling the impact of host genetics and factors on the urinary microbiome in a young population. mBio. 2024;15(12):e0277324. DOI: 10.1128/mbio.02773-24. PMID: 39513726.
Qin Y, Havulinna AS, Liu Y, Jousilahti P, Ritchie SC, Tokolyi A, et al. Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort. Nat Genet. 2022;54(2):134-42. DOI: 10.1038/s41588-021-00991-z. PMID: 35115689.
Frishman S, Nuriel-Ohayon M, Turjeman S, Pinto Y, Yariv O, Tenenbaum-Gavish K, et al. Positive effects of diet-induced microbiome modification on GDM in mice following human faecal transfer. Gut. 2024;73(10):e17. DOI: 10.1136/gutjnl-2023-331456. PMID: 38182136.
Pinto Y, Frishman S, Turjeman S, Eshel A, Nuriel-Ohayon M, Shrossel O, et al. Gestational diabetes is driven by microbiota-induced inflammation months before diagnosis. Gut. 2023;72(5):918-28. DOI: 10.1136/gutjnl-2022-328406. PMID: 36627187.
Crusell MKW, Hansen TH, Nielsen T, Allin KH, Rühlemann MC, Damm P, et al. Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum. Microbiome. 2018;6(1):89. DOI: 10.1186/s40168-018-0472-x. PMID: 29764499.
Collado MC, Isolauri E, Laitinen K, Salminen S. Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr. 2008;88(4):894-9. DOI: 10.1093/ajcn/88.4.894. PMID: 18842773.
Calatayud M, Koren O, Collado MC. Maternal Microbiome and Metabolic Health Program Microbiome Development and Health of the Offspring. Trends Endocrinol Metab. 2019;30(10):735-44. DOI: 10.1016/j.tem.2019.07.021. PMID: 31493988.
Stanislawski MA, Dabelea D, Wagner BD, Sontag MK, Lozupone CA, Eggesbø M. Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants. Microbiome. 2017;5(1):113. DOI: 10.1186/s40168-017-0332-0. PMID: 28870230.
Turjeman S, Collado MC, Koren O. The Gut Microbiome in Pregnancy and Pregnancy Complications. Current Opinion in Endocrine and Metabolic Research. 2021;18:133-8. DOI: 10.1016/j.coemr.2021.03.004.
Collado MC, Isolauri E, Laitinen K, Salminen S. Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy. Am J Clin Nutr. 2010;92(5):1023-30. DOI: 10.3945/ajcn.2010.29877. PMID: 20844065.
Tun HM, Bridgman SL, Chari R, Field CJ, Guttman DS, Becker AB, et al. Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators. Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring. JAMA Pediatr. 2018;172(4):368-77. DOI: 10.1001/jamapediatrics.2017.5535. PMID: 29459942.
Singh SB, Madan J, Coker M, Hoen A, Baker ER, Karagas MR, et al. Does birth mode modify associations of maternal pre-pregnancy BMI and gestational weight gain with the infant gut microbiome? Int J Obes (Lond). 2020;44(1):23-32. DOI: 10.1038/s41366-018-0273-0. PMID: 30765892.
Baumann-Dudenhoeffer AM, D'Souza AW, Tarr PI, Warner BB, Dantas G. Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes. Nat Med. 2018;24(12):1822-9. DOI: 10.1038/s41591-018-0216-2. PMID: 30374198.
Cerdó T. Maternal Obesity Is Associated with Gut Microbial Metabolic Potential in offspring During Infancy. Journal of Physiology and Biochemistry. 2018;74(1):159-69. DOI: 10.1007/s13105-017-0577-x. PMID: 28819768.
Deng L, Taelman S, Olm MR, Toe LC, Balini E, Ouedraogo W-BLO, et al. Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: a randomized controlled trial. Nature Communications. 2025;16(1):2683. DOI: 10.1038/s41467-025-57838-y. PMID: 40102379.
Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, et al. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018;9(1):4462. DOI: 10.1038/s41467-018-06929-0. PMID: 30367045.
Wang J, Zheng J, Shi W, Du N, Xu X, Zhang Y, et al. Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus. Gut. 2018;67(9):1614-25. DOI: 10.1136/gutjnl-2018-315988. PMID: 29760169.
Wagner VE, Dey N, Guruge J, Hsiao A, Ahern PP, Semenkovich NP, et al. Effects of a Gut Pathobiont in a Gnotobiotic Mouse Model of Childhood Undernutrition. Science Translational Medicine. 2016;(8):366ra164. DOI: 10.1126/scitranslmed.aah4669. PMID: 27881825.
Ponzo V, Ferrocino I, Zarovska A, Amenta MB, Leone F, Monzeglio C, et al. The Microbiota Composition of the Offspring of Patients with Gestational Diabetes Mellitus (GDM). PLoS ONE. 2019;(14):0226545. DOI: 10.1371/journal.pone.0226545. PMID: 31841548.
Nieto-Ruiz A, Cerdó T, Jordano B, Torres-Espínola FJ, Escudero-Marín M, García-Ricobaraza M, et al. Maternal weight, gut microbiota, and the association with early childhood behavior: the PREOBE follow-up study. Child Adolesc Psychiatry Ment Health. 2023;17(1):41. DOI: 10.1186/s13034-023-00589-9. PMID: 36945049.
Kaisanlahti A, Turunen J, Byts N, Samoylenko A, Bart G, Virtanen N, et al. Maternal microbiota communicates with the fetus through microbiota-derived extracellular vesicles. Microbiome. 2023;11(1):249. DOI: 10.1186/s40168-023-01694-9. PMID: 37953319.
Li Y, Toothaker JM, Ben-Simon S, Ozeri L, Schweitzer R, McCourt BT, et al. In utero human intestine harbors unique metabolome, including bacterial metabolites. JCI Insight. 2020;5(21):e138751. DOI: 10.1172/jci.insight.138751. PMID: 33001863.
Wang W, Gu W, Schweitzer R, Koren O, Khatib S, Tseng G, Konnikova L. In utero human intestine contains maternally derived bacterial metabolites. Microbiome. 2025;13(1):116. DOI: 10.1186/s40168-025-02110-0. PMID: 40329366.
Koren O, Konnikova L, Brodin P, Mysorekar IU, Collado MC. The maternal gut microbiome in pregnancy: implications for the developing immune system. Nat Rev Gastroenterol Hepatol. 2024;21(1):35-45. DOI: 10.1038/s41575-023-00864-2. PMID: 38097774.
Mitchell CM, Mazzoni C, Hogstrom L, Bryant A, Bergerat A, Cher A, et al. Delivery Mode Affects Stability of Early Infant Gut Microbiota. Cell Rep Med. 2020;1(9):100156. DOI: 10.1016/j.xcrm.2020.100156. PMID: 33377127.
Chen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, et al. Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the ALPHABET consortium. BMC Med. 2021;19(1):33. DOI: 10.1186/s12916-021-01908-7. PMID: 33612114.
Sasaki T, Kawamura M, Okuno C, Lau K, Riel J, Lee MJ, Miller C. Impact of Maternal Mediterranean-Type Diet Adherence on Microbiota Composition and Epigenetic Programming of Offspring. Nutrients. 2023;16(1):47. DOI: 10.3390/nu16010047. PMID: 38201877.
Dawson SL, O'Hely M, Jacka FN, Ponsonby AL, Symeonides C, Loughman A, et al. Maternal Prenatal Gut Microbiota Composition Predicts Child Behaviour. EBioMedicine. 2021;(68):103400. DOI: 10.1016/j.ebiom.2021.103400. PMID: 34098340.
Gete DG, Waller M, Mishra GD. Effects of maternal diets on preterm birth and low birth weight: a systematic review. Br J Nutr. 2020;123(4):446-61. DOI: 10.1017/S0007114519002897. PMID: 31711550.
Henderickx JGE, Zwittink RD, van Lingen RA, Knol J, Belzer C. The Preterm Gut Microbiota: An Inconspicuous Challenge in Nutritional Neonatal Care. Front Cell Infect Microbiol. 2019;9:85. DOI: 10.3389/fcimb.2019.00085. PMID: 31001489.
Desorcy‐Scherer K, Bendixen MM, Parker LA. Determinants of the Very Low‐Birth‐Weight Infant's Intestinal Microbiome: A Systematic Review. Journal of Perinatal and Neonatal Nursing. 2020;(34):257-75. DOI: 10.1097/JPN.0000000000000506. PMID: 32697547.
Hiltunen H, Hanani H, Luoto R, Turjeman S, Ziv O, Isolauri E, et al. Preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice. Cell Rep Med. 2021;2(11):100447. DOI: 10.1016/j.xcrm.2021.100447. PMID: 34841294.
Maher SE, O'Brien EC, Moore RL, Byrne DF, Geraghty AA, Saldova R, et al. The association between the maternal diet and the maternal and infant gut microbiome: a systematic review. Br J Nutr. 2023;129(9):1491-9. DOI: 10.1017/S0007114520000847. PMID: 32129734.
Vuillermin PJ, O'Hely M, Collier F, Allen KJ, Tang MLK, Harrison LC, et al. Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring. Nat Commun. 2020;11(1):1452. DOI: 10.1038/s41467-020-14552-1. PMID: 32210229.
Fan HY, Tung YT, Yang YSH, Hsu JB, Lee CY, Chang TH, et al. Maternal Vegetable and Fruit Consumption during Pregnancy and Its Effects on Infant Gut Microbiome. Nutrients. 2021;13(5):1559. DOI: 10.3390/nu13051559. PMID: 34063157.
Makki K, Deehan EC, Walter J, Bäckhed F. The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease. Cell Host Microbe. 2018;23(6):705-15. DOI: 10.1016/j.chom.2018.05.012. PMID: 29902436.
Flores Ventura E, Lane JA, Turjeman S, Vidra N, Weiss GA, Gross G, et al. ILSI Europe perspective review: site-specific microbiota changes during pregnancy associated with biological consequences and clinical outcomes: opportunities for probiotic interventions. Gut Microbes. 2025;17(1):2501186. DOI: 10.1080/19490976.2025.2501186. PMID: 40397816.
Alemu BK, Wu L, Azeze GG, Lau SL, Wang Y, Wang CC. Microbiota-targeted interventions and clinical implications for maternal-offspring health: An umbrella review of systematic reviews and meta-analyses of randomised controlled trials. J Glob Health. 2024;14:04177. DOI: 10.7189/jogh.14.04177. PMID: 39269153.
Bisanz JE, Enos MK, PrayGod G, Seney S, Macklaim JM, Chilton S, et al. Microbiota at Multiple Body Sites during Pregnancy in a Rural Tanzanian Population and Effects of Moringa-Supplemented Probiotic Yogurt. Appl Environ Microbiol. 2015;81(15):4965-75. DOI: 10.1128/AEM.00780-15. PMID: 25979893.
Erçelik HC, Kaya V. The effects of fermented food consumption in pregnancy on neonatal and infant health: An integrative review. J Pediatr Nurs. 2024;75:173-9. DOI: 10.1016/j.pedn.2023.12.019. PMID: 38160470.
Tan T, Xiao D, Li Q, Zhong C, Hu W, Guo J, et al. Maternal yogurt consumption during pregnancy and infantile eczema: a prospective cohort study. Food Funct. 2023;14(4):1929-36. DOI: 10.1039/d2fo02064e. PMID: 36723007.
Sugimori N, Hamazaki K, Matsumura K, Kasamatsu H, Tsuchida A, Inadera H, et al. Association between maternal fermented food consumption and infant sleep duration: The Japan Environment and Children's Study. PLoS One. 2019;14(10):e0222792. DOI: 10.1371/journal.pone.0222792. PMID: 31584958.
Inoue M, Sugimori N, Hamazaki K, Matsumura K, Tsuchida A, Inadera H; Japan Environment and Children’s Study (JECS) Group. Association Between Maternal Fermented Food Consumption and Child Sleep Duration at the Age of 3 Years: The Japan Environment and Children's Study. BMC Public Health. 2022;(22):1504. DOI: 10.1186/s12889-022-13805-6. PMID: 35933371.
Lundgren SN, Madan JC, Emond JA, Morrison HG, Christensen BC, Karagas MR, et al. Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner. Microbiome. 2018;6(1):109. DOI: 10.1186/s40168-018-0490-8. PMID: 29973274.
Simione M, Harshman SG, Castro I, Linnemann R, Roche B, Ajami NJ, et al. Maternal Fish Consumption in Pregnancy Is Associated with a Bifidobacterium‐Dominant Microbiome Profile in Infants. Current Developments in Nutrition 2020;4(1):nzz133. DOI: 10.1093/cdn/nzz133. PMID: 31875205.
García-Mantrana I, Selma-Royo M, González S, Parra-Llorca A, Martínez-Costa C, Collado MC. Distinct maternal microbiota clusters are associated with diet during pregnancy: impact on neonatal microbiota and infant growth during the first 18 months of life. Gut Microbes. 2020;11(4):962-78. DOI: 10.1080/19490976.2020.1730294. PMID: 32167021.
Buffington SA, Di Prisco GV, Auchtung TA, Ajami NJ, Petrosino JF, Costa-Mattioli M. Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring. Cell. 2016;165(7):1762-75. DOI: 10.1016/j.cell.2016.06.001. PMID: 27315483.
Xie R, Sun Y, Wu J, Huang S, Jin G, Guo Z, et al. Maternal High Fat Diet Alters Gut Microbiota of Offspring and Exacerbates DSS-Induced Colitis in Adulthood. Front Immunol. 2018;9:2608. DOI: 10.3389/fimmu.2018.02608. PMID: 30483266.
Wankhade UD. Maternal High‐Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in. Gut Microbial Ecology in Mice Sci Rep. 2018;(8):16502. DOI: 10.1038/s41598-018-34453-0. PMID: 30405201.
Ratsika A, Codagnone MG, Bastiaanssen TFS, Hoffmann Sarda FA, Lynch CMK, Ventura-Silva AP, et al. Maternal high-fat diet-induced microbiota changes are associated with alterations in embryonic brain metabolites and adolescent behaviour. Brain Behav Immun. 2024;121:317-30. DOI: 10.1016/j.bbi.2024.07.020. PMID: 39032541.
Daliry A, Pereira ENGDS. Role of Maternal Microbiota and Nutrition in Early-Life Neurodevelopmental Disorders. Nutrients. 2021;13(10):3533. DOI: 10.3390/nu13103533. PMID: 34684534.
Hsieh H‐Y, Chen Y‐C, Hsu M‐H, Yu HR, Su CH, Tain YL, et al. Maternal Iron Deficiency Programs Offspring Cognition and Its Relationship with Gastrointestinal Microbiota and Metabolites. IJERPH. 2020;(17):6070. DOI: 10.3390/ijerph17176070. PMID: 32825437.
Kamng'ona AW, Young R, Arnold CD, Patson N, Jorgensen JM, Kortekangas E, et al. Provision of Lipid-Based Nutrient Supplements to Mothers During Pregnancy and 6 Months Postpartum and to Their Infants from 6 to 18 Months Promotes Infant Gut Microbiota Diversity at 18 Months of Age but Not Microbiota Maturation in a Rural Malawian Setting: Secondary Outcomes of a Randomized Trial. J Nutr. 2020;150(4):918-28. DOI: 10.1093/jn/nxz298. PMID: 31909811.
Molani-Gol R, Rafraf M. Maternal vitamin D in pregnancy and infant's gut microbiota: a systematic review. Front Pediatr. 2023;11:1248517. DOI: 10.3389/fped.2023.1248517. PMID: 37915988.
Talsness CE, Penders J, Jansen EHJM, Damoiseaux J, Thijs C, Mommers M. Influence of vitamin D on key bacterial taxa in infant microbiota in the KOALA Birth Cohort Study. PLoS One. 2017;12(11):e0188011. DOI: 10.1371/journal.pone.0188011. PMID: 29121673.
Drall KM, Field CJ, Haqq AM, de Souza RJ, Tun HM, Morales-Lizcano NP, et al. Vitamin D supplementation in pregnancy and early infancy in relation to gut microbiota composition and C. difficile colonization: implications for viral respiratory infections. Gut Microbes. 2020;12(1):1799734. DOI: 10.1080/19490976.2020.1799734. PMID: 32779963.
Song Q, Li Y, Zhou T, Xiao M, Xiao B, Wang M, Zhu Y. Maternal Vitamin D Status During Pregnancy and Infant's Gut Microbiota: A Prospective Cohort Study. Frontiers in Nutrition. 2024;11:1428356. DOI: 10.3389/fnut.2024.1428356. PMID: 39135559.
Hsu CN, Lin YJ, Hou CY, Tain YL. Maternal Administration of Probiotic or Prebiotic Prevents Male Adult Rat Offspring against Developmental Programming of Hypertension Induced by High Fructose Consumption in Pregnancy and Lactation. Nutrients. 2018;10(9):1229. DOI: 10.3390/nu10091229. PMID: 30181501.
Laforest-Lapointe I, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Sears MR, et al. Maternal consumption of artificially sweetened beverages during pregnancy is associated with infant gut microbiota and metabolic modifications and increased infant body mass index. Gut Microbes. 2021;13(1):1-15. DOI: 10.1080/19490976.2020.1857513. PMID: 33382954.
Whelan K, Bancil AS, Lindsay JO, Chassaing B. Ultra-processed foods and food additives in gut health and disease. Nat Rev Gastroenterol Hepatol. 2024;21(6):406-27. DOI: 10.1038/s41575-024-00893-5. PMID: 38388570.
Tang Q, Wang C, Jin G, Li Y, Hou H, Wang X, et al. Early Life Dietary Emulsifier Exposure Predisposes the Offspring to Obesity Through Gut Microbiota‐FXR Axis. Food Research International. 2022;162(Pt_A):111921. DOI: 10.1016/j.foodres.2022.111921. PMID: 36461273.
Liang Y, Liu D, Li Y, Hou H, Li P, Ma X, et al. Maternal Polysorbate 80 Intake Promotes Offspring Metabolic Syndrome Through Vertical Microbial Transmission in Mice. Science of The Total Environment. 2024;909:168624. DOI: 10.1016/j.scitotenv.2023.168624. PMID: 37979881.
Issa M, Michaudel C, Guinot M, Grauso-Culetto M, Guillon B, Lecardonnel J, et al. Long‐term Exposure from Perinatal Life to Food‐grade TiO2 Alters Intestinal Homeostasis and Predisposes to Food Allergy in Young Mice. Allergy. 2024;79(2):471-84. DOI: 10.1111/all.15960. PMID: 38010857.
Aliya S, Alhammadi M, Ilangovan S, Soobin H, Sujina T, Byoungchul S, et al. Microplastics: An Emerging Environmental Risk Factor for Gut Microbiota Dysbiosis and Cancer Development? Environmental Chemistry and Ecotoxicology. 2025;7:706-28. DOI: 10.1016/j.enceco.2025.03.005.
Nissen L, Spisni E, Spigarelli R, Casciano F, Valerii MC, Fabbri E, et al. Single exposure of food-derived polyethylene and polystyrene microplastics profoundly affects gut microbiome in an in vitro colon model. Environ Int. 2024;190:108884. DOI: 10.1016/j.envint.2024.108884. PMID: 39004044.
The impact of microplastics on the gut microbiome and health – A food safety perspective. Food Safety and Quality Series, No.21. Rome: FAO; 2023. 58 p. DOI: 10.4060/cc5294en.
Elmassry MM, Zayed A, Farag MA. Gut homeostasis and microbiota under attack: impact of the different types of food contaminants on gut health. Crit Rev Food Sci Nutr. 2022;62(3):738-63. DOI: 10.1080/10408398.2020.1828263. PMID: 33063532.
Matsuzaki R, Gunnigle E, Geissen V, Clarke G, Nagpal J, Cryan JF. Pesticide exposure and the microbiota-gut-brain axis. ISME J. 2023;17(8):1153-1166. DOI: 10.1038/s41396-023-01450-9. PMID: 37328570.
The impact of veterinary drug residues on the gut microbiome and human health – A food safety perspective. Food Safety and Quality Series, No.20. Rome: FAO; 2023. 98 p. DOI: 10.4060/cc5301en.
The impact of pesticide residues on the gut microbiome and human health – A food safety perspective. Food Safety and Quality Series, No.19. Rome: FAO; 2023. 110 p. DOI: 10.4060/cc5306en.
Calatayud Arroyo M, García Barrera T, Callejón Leblic B, Arias Borrego A, Collado MC. A review of the impact of xenobiotics from dietary sources on infant health: Early life exposures and the role of the microbiota. Environ Pollut. 2021;269:115994. DOI: 10.1016/j.envpol.2020.115994. PMID: 33310490.
Sethi S, Keil Stietz KP, Valenzuela AE, Klocke CR, Silverman JL, Puschner B, et al. Developmental Exposure to a Human-Relevant Polychlorinated Biphenyl Mixture Causes Behavioral Phenotypes That Vary by Sex and Genotype in Juvenile Mice Expressing Human Mutations That Modulate Neuronal Calcium. Front Neurosci. 2021;15:766826. DOI: 10.3389/fnins.2021.766826. PMID: 34938155.
Pheeha SM, Tamuzi JL, Chale-Matsau B, Manda S, Nyasulu PS. A Scoping Review Evaluating the Current State of Gut Microbiota Research in Africa. Microorganisms. 2023;11(8):2118. DOI: 10.3390/microorganisms11082118. PMID: 37630678.
Bastos-Amador P, Duarte EL, Torres J, Caldeira AT, Silva I, Salvador C, et al. Maternal dietary exposure to mycotoxin aflatoxin B1 promotes intestinal immune alterations and microbiota modifications increasing infection susceptibility in mouse offspring. Food Chem Toxicol. 2023;173:113596. DOI: 10.1016/j.fct.2022.113596. PMID: 36603704.
Pu Y, Yang J, Chang L, Qu Y, Wang S, Zhang K, et al. Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2020;117(21):11753-9. DOI: 10.1073/pnas.1922287117. PMID: 32398374.
Shevchenko AS, Shevchenko VV, Pomogaybo KG, Danylchenko SI, Brown GW, Shumskyi OL, et al. The system of risk factors for diseases in valeolog-ical disciplines. Inter Collegas. 2025;12(1):48-65. DOI: 10.35339/ic.2025.12.1.ssp.
Forbes JD, Azad MB, Vehling L, Tun HM, Konya TB, Guttman DS, et al. Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators. Association of Exposure to Formula in the Hospital and Subsequent Infant Feeding Practices With Gut Microbiota and Risk of Overweight in the First Year of Life. JAMA Pediatr. 2018;172(7):e181161. DOI: 10.1001/jamapediatrics.2018.1161. PMID: 29868719.
Stanislawski MA, Dabelea D, Wagner BD, Iszatt N, Dahl C, Sontag MK, et al. Gut Microbiota in the First 2 Years of Life and the Association with Body Mass Index at Age 12 in a Norwegian Birth Cohort. mBio. 2018;9(5):e01751-18. DOI: 10.1128/mBio.01751-18. PMID: 30352933.
Laursen MF, Bahl MI, Michaelsen KF, Licht TR. First Foods and Gut Microbes. Front Microbiol. 2017;8:356. DOI: 10.3389/fmicb.2017.00356. PMID: 28321211.
Differding MK, Benjamin-Neelon SE, Hoyo C, Østbye T, Mueller NT. Timing of complementary feeding is associated with gut microbiota diversity and composition and short chain fatty acid concentrations over the first year of life. BMC Microbiol. 2020;20(1):56. DOI: 10.1186/s12866-020-01723-9. PMID: 32160858.
Pluymen LPM, Wijga AH, Gehring U, Koppelman GH, Smit HA, van Rossem L. Early introduction of complementary foods and childhood overweight in breastfed and formula-fed infants in the Netherlands: the PIAMA birth cohort study. Eur J Nutr. 2018;57(5):1985-93. DOI: 10.1007/s00394-018-1639-8. PMID: 29470690.
Thompson AL, Monteagudo-Mera A, Cadenas MB, Lampl ML, Azcarate-Peril MA. Milk- and solid-feeding practices and daycare attendance are associated with differences in bacterial diversity, predominant communities, and metabolic and immune function of the infant gut microbiome. Front Cell Infect Microbiol. 2015;5:3. DOI: 10.3389/fcimb.2015.00003. PMID: 25705611.
Tsukuda N, Yahagi K, Hara T, Watanabe Y, Matsumoto H, Mori H, et al. Key bacterial taxa and metabolic pathways affecting gut short-chain fatty acid profiles in early life. ISME J. 2021;15(9):2574-90. DOI: 10.1038/s41396-021-00937-7. PMID: 33723382.
Derrien M, Alvarez AS, de Vos WM. The Gut Microbiota in the First Decade of Life. Trends Microbiol. 2019;27(12):997-1010. DOI: 10.1016/j.tim.2019.08.001. PMID: 31474424.
Logan K, Perkin MR, Marrs T, Radulovic S, Craven J, Flohr C, et al. Early Gluten Introduction and Celiac Disease in the EAT Study: A Prespecified Analysis of the EAT Randomized Clinical Trial. JAMA Pediatr. 2020;174(11):1041-7. DOI: 10.1001/jamapediatrics.2020.2893. PMID: 32986087.
Lund-Blix NA, Tapia G, Mårild K, Brantsæter AL, Eggesbø M, Mandal S, et al. Maternal fibre and gluten intake during pregnancy and risk of childhood celiac disease: the MoBa study. Sci Rep. 2020;10(1):16439. DOI: 10.1038/s41598-020-73244-4. PMID: 33009438.
Sanchez KK, Chen GY, Schieber AMP, Redford SE, Shokhirev MN, Leblanc M, et al. Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen. Cell. 2018;175(1):146-58.e15. DOI: 10.1016/j.cell.2018.07.016. PMID: 30100182.
Karamantziani T, Pouliakis A, Xanthos T, Ekmektzoglou K, Paliatsiou S, Sokou R, Iacovidou N. The Effect of Oral Iron Supplementation/Fortification on the Gut Microbiota in Infancy: A Systematic Review and Meta-Analysis. Children (Basel). 2024;11(2):231. DOI: 10.3390/children11020231. PMID: 38397343.
Popovic A, Bourdon C, Wang PW, Guttman DS, Soofi S, Bhutta ZA, et al. Micronutrient Supplements Can Promote Disruptive Protozoan and Fungal Communities in the Developing Infant Gut. Nature Communications. 2021;(12):6729. DOI: 10.1038/s41467-021-27010-3. PMID: 34795270.
Finlayson‐Trick EC, Fischer JA, Goldfarb DM, Karakochuk CD. The Effects of Iron Supplementation and Fortification on the Gut Microbiota: A Review. Gastrointestinal Disorders. 2020;(2):327-40. DOI: 10.3390/gidisord2040030.
Tang M, Frank DN, Hendricks AE, Ir D, Esamai F, Liechty E, et al. Iron in Micronutrient Powder Promotes an Unfavorable Gut Microbiota in Kenyan Infants. Nutrients. 2017;9(7):776. DOI: 10.3390/nu9070776. PMID: 28753958.
Jaeggi T, Kortman GA, Moretti D, Chassard C, Holding P, Dostal A, et al. Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut. 2015;64(5):731-42. DOI: 10.1136/gutjnl-2014-307720. PMID: 25143342.
Paganini D, Uyoga MA, Kortman GAM, Cercamondi CI, Winkler HC, Boekhorst J, et al. Iron‐containing Micronutrient Powders Modify the Effect of Oral Antibiotics on the Infant Gut Microbiome and Increase Post‐antibiotic Diarrhoea Risk: A Controlled Study in Kenya. Gut. 2019;(68):645-53. DOI:10.1136/gutjnl-2018-317399. PMID: 30448776.
Tang M, Frank DN, Sherlock L, Ir D, Robertson CE, Krebs NF. Effect of Vitamin E With Therapeutic Iron Supplementation on Iron Repletion and Gut Microbiome in US Iron Deficient Infants and Toddlers. J Pediatr Gastroenterol Nutr. 2016;63(3):379-85. DOI: 10.1097/MPG.0000000000001154. PMID: 27548249.
Ghanchi A, James PT, Cerami C. Guts, Germs, and Iron: A Systematic Review on Iron Supplementation, Iron Fortification, and Diarrhea in Children Aged 4-59 Months. Curr Dev Nutr. 2019;3(3):nzz005. DOI: 10.1093/cdn/nzz005. PMID: 30891538.
Matsuyama M, Morrison M, Cao KL, Pruilh S, Davies PSW, Wall C, et al. Dietary intake influences gut microbiota development of healthy Australian children from the age of one to two years. Sci Rep. 2019;9(1):12476. DOI: 10.1038/s41598-019-48658-4. PMID: 31462648.
Smith-Brown P, Morrison M, Krause L, Davies PS. Dairy and plant based food intakes are associated with altered faecal microbiota in 2 to 3 year old Australian children. Sci Rep. 2016;6:32385. DOI: 10.1038/srep32385. PMID: 27694811.
Tan H, Zhai Q, Chen W. Investigations of Bacteroides spp. towards next-generation probiotics. Food Res Int. 2019;116:637-44. DOI: 10.1016/j.foodres.2018.08.088. PMID: 30716990.
Henke MT, Kenny DJ, Cassilly CD, Vlamakis H, Xavier RJ, Clardy J. Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide. Proc Natl Acad Sci USA. 2019;116(26):12672-7. DOI: 10.1073/pnas.1904099116. PMID: 31182571.
De Franchis R, Bozza L, Canale P, Chiacchio M, Cortese P, D'Avino A, et al. The Effect of Weaning with Adult Food Typical of the Mediterranean Diet on Taste Development and Eating Habits of Children: A Randomized Trial. Nutrients. 2022;14(12):2486. DOI: 10.3390/nu14122486. PMID: 35745216.
Zhong H, Penders J, Shi Z, Ren H, Cai K, Fang C, et al. Impact of early events and lifestyle on the gut microbiota and metabolic phenotypes in young school-age children. Microbiome. 2019;7(1):2. DOI: 10.1186/s40168-018-0608-z. PMID: 30609941.
Ruggles KV, Wang J, Volkova A, Contreras M, Noya-Alarcon O, Lander O, et al. Changes in the Gut Microbiota of Urban Subjects during an Immersion in the Traditional Diet and Lifestyle of a Rainforest Village. mSphere. 2018;3(4):e00193-18. DOI: 10.1128/mSphere.00193-18. PMID: 30158281.
Burns AM, Zitt MA, Rowe CC, Langkamp-Henken B, Mai V, Nieves C Jr, et al. Diet quality improves for parents and children when almonds are incorporated into their daily diet: a randomized, crossover study. Nutr Res. 2016;36(1):80-9. DOI: 10.1016/j.nutres.2015.11.004. PMID: 26773784.
Frese SA, Hutton AA, Contreras LN, Shaw CA, Palumbo MC, Casaburi G, et al. Persistence of Supplemented Bifidobacterium longum subsp. infantis EVC001 in Breastfed Infants. mSphere. 2017;2(6):e00501-17. DOI: 10.1128/mSphere.00501-17. PMID: 29242832.
Jiang W, Ni B, Liu Z, Liu X, Xie W, Wu IXY, et al. The Role of Probiotics in the Prevention and Treatment of Atopic Dermatitis in Children: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. Paediatr Drugs. 2020;22(5):535-49. DOI: 10.1007/s40272-020-00410-6. PMID: 32748341.
Alshaikh B, Samara J, Moossavi S, Ferdous T, Soraisham A, Dersch-Mills D, et al Multi-strain probiotics for extremely preterm infants: a randomized controlled trial. Pediatr Res. 2022;92(6):1663-70. DOI: 10.1038/s41390-022-02004-z. PMID: 35314794.
Lee-Sarwar KA, Kelly RS, Lasky-Su J, Zeiger RS, O'Connor GT, Sandel MT, et al Integrative analysis of the intestinal metabolome of childhood asthma. J Allergy Clin Immunol. 2019;144(2):442-54. DOI: 10.1016/j.jaci.2019.02.032. PMID: 30914378.
Levin ME, Botha M, Basera W, Facey-Thomas HE, Gaunt B, Gray CL, et al. Environmental factors associated with allergy in urban and rural children from the South African Food Allergy (SAFFA) cohort. J Allergy Clin Immunol. 2020;145(1):415-26. DOI: 10.1016/j.jaci.2019.07.048. PMID: 31606483.
Wastyk HC, Fragiadakis GK, Perelman D, Dahan D, Merrill BD, Yu FB, et al. Gut-microbiota-targeted diets modulate human immune status. Cell. 2021;184(16):4137-53.e14. DOI: 10.1016/j.cell.2021.06.019. PMID: 34256014.
Mahdavinia M, Rasmussen HE, Botha M, Binh Tran TD, Van den Berg JP, Sodergren E, et al. Effects of diet on the childhood gut microbiome and its implications for atopic dermatitis. J Allergy Clin Immunol. 2019;143(4):1636-7.e5. DOI: 10.1016/j.jaci.2018.11.034. PMID: 30578881.
Goldberg MR, Mor H, Magid Neriya D, Magzal F, Muller E, Appel MY, et al. Microbial signature in IgE-mediated food allergies. Genome Med. 2020;12(1):92. DOI: 10.1186/s13073-020-00789-4. PMID: 33109272.
Ця робота ліцензується відповідно до Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.